Reactive case detection around falciparum malaria cases in Cambodia presents a low output. We improved it by including individuals occupationally coexposed with index case patients and using polymerase chain reaction-based diagnosis. The positivity rate increased from 0.16% to 3.9%.
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The common chemical logic of 'bridged' peroxo species in mononuclear non-heme iron systems.
Crit Rev Biochem Mol Biol
January 2025
Department of Chemistry, Emory University, Atlanta, GA, USA.
Mononuclear non-heme iron enzymes catalyze a wide array of important oxidative transformations. They are correspondingly diverse in both structure and mechanism. Despite significant evolutionary distance, it is becoming increasingly apparent that these enzymes nonetheless illustrate a compelling case of mechanistic convergence the formation of peroxo species bridging metal and substrate.
View Article and Find Full Text PDFNavigating the dichotomy of reactive oxygen, nitrogen, and sulfur species: detection strategies and therapeutic interventions.
RSC Chem Biol
January 2025
Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research Jakkur P.O. Bengaluru Karnataka 560064 India
Reactive oxygen, nitrogen and sulfur species (RONSS) collectively encompasses a variety of energetically dynamic entities that emerge as inherent characteristics of aerobic life. This broad category includes reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS). A conundrum arises from the indispensable role of RONSS in redox signalling, while its overproduction in the mitochondria poses deleterious effects.
View Article and Find Full Text PDFEvaluation of antihistamine-refractory chronic urticaria patients who used biological agent treatment in terms of cardiovascular risk.
Postepy Dermatol Alergol
December 2024
Department of Allergy and Immunology, Tepecik Education and Research Hospital, İzmir, Turkey.
Introduction: The idea that chronic inflammatory processes may play a role in the etiopathogenesis of both treatment - refractory chronic spontaneous urticaria and cardiovascular diseases is an important research topic.
Aim: Within the scope of this research, we aimed to elucidate a new perspective on the follow-up of chronic urticaria patients by evaluating the 10-year cardiovascular risk and metabolic syndrome in resistant chronic spontaneous urticaria patients who were unresponsive to maximum antihistamine treatment.
Material And Methods: A total of 170 individuals who applied to our institution's Health Science University, Tepecik Education and Research Hospital, allergy and immunology outpatient clinic have been analysed in this retrospective case-control study.
Electrolyte reactivity on electrode surfaces for active species formation and Reactive Red X-3B degradation in electrochemical treatment of dyeing wastewater.
J Environ Manage
January 2025
School of Environment Science and Engineering, Donghua University, Shanghai, 201620, PR China; Shanghai Institution of Pollution Control and Ecological Security, Shanghai, 200092, PR China; State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry, Donghua University, Shanghai, 201620, PR China.
The pivotal role of electrolytes such as NaSO and NaCl in electrochemical treatment of dyeing wastewater was investigated by comparing recalcitrant Reactive Red X-3B (RRX-3B) degradation rates, active species formation and intermediates generation in a double-chamber cell. It was found that similar reactive oxygen species (ROS) formed in the anodic chamber are OH and O, in the cathodic chamber is O with different electrolytes, while this is not the case for ROS contribution, RRX-3B degradation kinetic and intermediates. NaCl favored the generation of O, faster decolorization (-N=N- cleavage), and organic intermediates degradation in the anodic chamber.
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