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Anti-panic effect of fluoxetine during late diestrus in female rats is mediated through GABAergic mechanisms in the dorsal periaqueductal gray.
Neurosci Lett
January 2025
Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo, Brazil. Electronic address:
Panic disorder is more frequent in women than in men. In women, vulnerability to panic is enhanced during the late luteal phase of the menstrual cycle. At this time secretion of progesterone and its neuroactive metabolite allopregnanolone (ALLO), which acts as a positive allosteric modulator of the actions of GABA at GABA receptors, decline sharply.
View Article and Find Full Text PDFSERCA Modulators Reveal Distinct Signaling and Functional Roles of T Lymphocyte Ca Stores.
Int J Mol Sci
November 2024
Department of Pharmaceutical Sciences, Thomas J. Long School of Pharmacy University of the Pacific, Stockton, CA 95211, USA.
The allosteric SERCA (Sarcoplasmic/Endoplasmic Reticulum Ca-ATPase) activator CDN1163 has been recently added to the group of pharmacological tools for probing SERCA function. We chose to investigate the effects of the compound on T lymphocyte Ca stores, using the well-described Jurkat T lymphocyte as a reliable cell system for Ca signaling pathways. Our study identified the lowest concentrations of the SERCA inhibitors thapsigargin (TG) and 2,5-di-( butyl)-1,4-benzohydroquinone (tBHQ) capable of releasing Ca, permitting the differentiation of the TG-sensitive SERCA 2b Ca store from the tBHQ-sensitive SERCA 3 Ca store.
View Article and Find Full Text PDFA therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.
Proc Natl Acad Sci U S A
August 2024
Department of Neurology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095.
Brain rhythms provide the timing for recruitment of brain activity required for linking together neuronal ensembles engaged in specific tasks. The γ-oscillations (30 to 120 Hz) orchestrate neuronal circuits underlying cognitive processes and working memory. These oscillations are reduced in numerous neurological and psychiatric disorders, including early cognitive decline in Alzheimer's disease (AD).
View Article and Find Full Text PDFThe Black Book of Psychotropic Dosing and Monitoring.
Psychopharmacol Bull
July 2024
Dr. Schatzberg is Kenneth T. Norris, Jr. professor in the Department of Psychiatry and Behavioral Sciences at the Stanford University School of Medicine in California.
Article Synopsis
- Several innovative treatments for mental health and neurodegenerative conditions have emerged or are set to be approved, including new antidepressants and drugs targeting PTSD and Alzheimer's disease.
- The new antidepressant Auvelity combines bupropion and dextromethorphan, enhancing efficacy and tolerability compared to bupropion alone, though its comparison to higher doses of bupropion is still uncertain.
- Zuranolone, a recent addition for treating postpartum depression, is more convenient than its predecessor brexanolone due to its oral formulation instead of requiring an intravenous infusion.
Cage effects on synaptic plasticity and its modulation in a mouse model of fragile X syndrome.
Philos Trans R Soc Lond B Biol Sci
July 2024
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.
Article Synopsis
- Fragile X syndrome (FXS) affects executive function and memory, and this study reviews the role of breeding strategies in understanding these impairments in a mouse model.
- The research highlights significant deficits in short-term potentiation (STP), long-term potentiation (LTP), and contextual fear conditioning (CFC) in knockout (KO) mice compared to non-littermate wild-type (WT) mice, although the expression of NMDAR subunits remained unchanged.
- Notably, the effectiveness of an NMDAR modulator (UBP714) to enhance LTP induction varied based on the breeding strategy used, indicating that these strategies may cause inconsistencies in research findings related to FXS.
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