Quantum mechanical calculations are employed to investigate the mechanism and origin of stereoinduction in asymmetric iron-catalyzed C(sp)-C(sp) cross-coupling reaction between Grignard reagents and α-chloroesters. A coherent mechanistic picture of this transformation is revealed. These results have broad implications for understanding the mechanisms of iron-catalyzed cross-coupling reactions and rational design of novel iron-based catalysts for asymmetric transformations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.7b06377 | DOI Listing |
Publication Analysis
Top Keywords
csp-csp cross-coupling
8
cross-coupling reaction
8
mechanism nakamura's
4
nakamura's bisphosphine-iron-catalyzed
4
bisphosphine-iron-catalyzed asymmetric
4
asymmetric csp-csp
4
reaction role
4
role spin
4
spin controlling
4
controlling arylation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!