Stromal restraint of cancer growth and progression-emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate-appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679442 | PMC |
| http://dx.doi.org/10.1016/j.ccell.2017.08.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids.
Stem Cells Transl Med
December 2024
Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative medicine owing to their self-renewal properties, multilineage differentiation, immunomodulatory effects, and angiogenic potential. MSC spheroids fabricated by 3D culture have recently shown enhanced therapeutic potential. MSC spheroids create a specialized niche with tight cell-cell and cell-extracellular matrix interactions, optimizing their cellular function by mimicking the in vivo environment.
View Article and Find Full Text PDFExtracellular vesicles support increased expansion of mesenchymal stromal cells on fetal membrane-derived decellularized extracellular matrix.
Cell Tissue Res
December 2024
Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Royal Women's Hospital Campus, Parkville, VIC, Australia.
Article Synopsis
- DMSC-derived extracellular vesicles (DMSC_EV) were shown to enhance DMSC proliferation and mobility on specific growth surfaces, particularly s-dAM.
- DMSC attachment varied based on the substrate, with increased attachment observed on decellularized surfaces and Matrigel when EVs were included.
- The study highlights that combining in vitro EVs and extracellular matrix (ECM) components can optimize the expansion and therapeutic potential of mesenchymal stem cells (MSCs) for various applications.
Effect of bone marrow niche on hematopoietic stem cells.
Histochem Cell Biol
December 2024
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hematopoietic stem cells (HSCs) reside in a milieu that supports their functions, differentiation, and survival. This niche consists of several types of cells, including mesenchymal stem/stromal cells, endothelial cells, osteoblasts, megakaryocytes, macrophages, adipocytes, lymphoid cells, and nerve fibers. The interactions between these cells and HSCs have a role in HSC fate.
View Article and Find Full Text PDFTumor-derived exosomes: Unravelling the pathogenesis of pancreatic cancer with liver metastases and exploring the potential for clinical translation.
Cancer Lett
December 2024
Department of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, 100034, China. Electronic address:
Pancreatic cancer (PC) is one of the most malignant solid cancers, and PC metastasis, particularly liver metastasis, is a major cause of cancer mortality. A key event in tumor metastasis is the formation of pre-metastatic niche (PMN), which provides a microenvironment conducive to tumor cells colonization and progression. Various molecules loaded in tumor-derived exosomes (TDEs) contribute to PMN formation and distant tumor metastasis, by regulating immune and stromal cell function, inducing angiogenesis, and promoting metabolic reprogramming.
View Article and Find Full Text PDFExosomal signaling in cancer metastasis: Molecular insights and therapeutic opportunities.
Arch Biochem Biophys
December 2024
Tumor Biology Laboratory, Department of Biotechnology, Savitribai Phule Pune University, Pune, 411 007, (MS), India. Electronic address:
Exosomes are membrane-bound extracellular vesicles that play a role in exchanging biological products across membranes and serve as intermediaries in intercellular communication to maintain normal homeostasis. Numerous molecules, including lipids, proteins, and nucleic acids are enclosed in exosomes. Exosomes are constantly released into the extracellular environment and exhibit distinct characteristics based on the secreted cells that produce them.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!