Department of Cardiovascular Medicine, Baystate Medical Center and Division of Cardiovascular Medicine, University of Massachusetts-Baystate, Springfield, MA, USA. Electronic address: https://twitter.com/AGoldsweig.
Introduction: The optimal revascularization strategy for patients with myocardial infarction (MI) and multivessel coronary artery disease (CAD) remains an area of research and debate. Fractional flow reserve (FFR)-guided complete revascularization (CR) by percutaneous coronary intervention (PCI) has emerged as an alternative to traditional culprit-only PCI.
Objective: To investigate the outcomes of FFR-guided CR versus culprit-only PCI in patients with MI and multivessel CAD.
Background: Unintentional injury deaths in sport and recreation represent a significant public health concern. This study analysed coronial recommendations related to such deaths, focusing on case specifics and recurring themes from January 2006 to December 2019.
Methods: This mixed-methods study used data from the Bureau du coroner du Québec.
Background: Mounting data indicates that extracellular vesicles (EVs) have the potential to improve the injury after a stroke. Pyroptosis is a recently identified kind of programmed cell death that initiates an inflammatory reaction. We aimed to ascertain the therapeutic implications and possible molecular processes of EVs obtained from adipose-derived stem cells (ADSCs) in inhibiting pyroptosis in ischemic stroke.
Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology and Department of Cancer Center of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China. Electronic address:
Ferroptosis is a novel form of regulated cell death characterized by iron-dependent lipid ROS accumulation, which is associated with various diseases, including acute organ injury, neurodegenerative disorders, and cancer. Pharmacological inhibition of ferroptosis has great potential for the treatment of these diseases. However, the clinical translation of many ferroptosis inhibitors is hindered by their inadequate activity or suboptimal pharmacokinetic profiles.
Key Laboratory of Efficient Utilization of Non-Grain Feed Resources, College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an 271017, China. Electronic address:
A close interplay exists between the gut and liver, known as the "gut-liver axis", which plays a vital role in health and disease. This research aimed to explore the effects of dietary formic acid polymer (FAP) addition on inflammatory injury in gut-liver axis of broilers due to lipopolysaccharide (LPS) challenge. Four hundred and fifty 1-day-old male Arbor Acres broilers were assigned to three treatment groups: (1) control (non-challenged, basal diet); (2) LPS (LPS-challenged, basal diet); (3) LPS+FAP (LPS-challenged, basal diet with 1,000 mg/kg FAP).
