AI Article Synopsis

  • - Three new insect-specific flaviviruses, named La Tina, Kampung Karu, and Long Pine Key, were discovered in mosquitoes from Peru, Malaysia, and the U.S. respectively.
  • - These viruses show closer similarities to mosquito-borne flavivirus pathogens rather than traditional insect-specific viruses.
  • - The study discusses the potential implications of these findings and the possible applications of these and similar arbovirus-related insect-specific flaviviruses.

Article Abstract

Three novel insect-specific flaviviruses, isolated from mosquitoes collected in Peru, Malaysia (Sarawak), and the United States, are characterized. The new viruses, designated La Tina, Kampung Karu, and Long Pine Key, respectively, are antigenically and phylogenetically more similar to the mosquito-borne flavivirus pathogens, than to the classical insect-specific viruses like cell fusing agent and flavivirus. The potential implications of this relationship and the possible uses of these and other arbovirus-related insect-specific flaviviruses are reviewed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929187PMC
http://dx.doi.org/10.4269/ajtmh.17-0350DOI Listing

Publication Analysis

Top Keywords

insect-specific flaviviruses
12
mosquito-borne flavivirus
8
flavivirus pathogens
8
characterization three
4
insect-specific
4
three insect-specific
4
flaviviruses relationship
4
relationship mosquito-borne
4
pathogens three
4
three novel
4

Similar Publications

The genus Alphavirus harbors arboviruses of great concern, such as the Chikungunya virus and the equine encephalitis viruses. Transmission of pathogenic alphaviruses by mosquitoes could be influenced by insect-specific alphaviruses such as Eilat virus (EILV). However, insect-specific alphaviruses are rarely found in wild mosquitoes and only a few have been described in the literature.

View Article and Find Full Text PDF

Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites.

PLoS One

December 2024

Department of Entomology, Texas A&M AgriLife, Texas A&M University, College Station, TX, United States of America.

Flaviviruses are a diverse group of RNA viruses known for their significant impact on human health worldwide. We generated a series of reporters that included cleavage sequences from the dengue virus type 2 polyprotein and co-transfected with plasmids encoding various flavivirus proteases into Aedes aegypti cells, followed by fluorescent imaging and western blot analysis for the determination of proteolytic cleavage. Recombinant flavivirus NS2B3 proteases from medically significant and insect-specific flaviviruses were able to process reporters encoding cleavage sequences from the dengue virus type 2 polyprotein in vitro including proteases from dengue virus types 1-4, Zika virus, yellow fever virus, Aedes flavivirus, and cell-fusing agent virus.

View Article and Find Full Text PDF

Emerging mosquito-borne flaviviruses.

mBio

December 2024

Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Article Synopsis
  • * There are over 50 flavivirus species, many previously exotic to humans, with the potential for emerging diseases, as seen in past outbreaks of Zika and West Nile viruses.
  • * The review focuses on mosquito-borne flaviviruses that can cause serious diseases in animals and potentially humans, exploring their pathology, animal models for study, and future research directions, including emerging threats like Usutu and Murray Valley encephalitis viruses.
View Article and Find Full Text PDF

RNA interference (RNAi) plays an essential role in mosquito antiviral immunity, but it is not known whether viral small interfering RNA (siRNA) profiles differ between mosquito-borne and mosquito-specific viruses. A pan-Orthoflavivirus analysis in cells revealed that viral siRNAs were evenly distributed across the viral genome of most representatives of the genus. In contrast, siRNA production was biased toward the 3' untranslated region (UTR) of the genomes of classical insect-specific flaviviruses (cISF), which was most pronounced for Kamiti River virus (KRV), a virus with a unique, 1.

View Article and Find Full Text PDF

Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate.

PLoS Pathog

October 2024

Department of Entomology, Virginia Tech, Blacksburg, Virginia, United States of America.

Flaviviruses represent a significant global health threat and relatively few licensed vaccines exist to protect against them. Insect-specific flaviviruses (ISFVs) are incapable of replication in humans and have emerged as a novel and promising tool for flavivirus vaccine development. ISFV-based flavivirus vaccines have shown exceptional safety, immunogenicity, and efficacy, however, a detailed assessment of the correlates of protection and immune responses induced by these vaccines are still needed for vaccine optimization.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!