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MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity.
PLoS Negl Trop Dis
December 2024
Systems Genomics Section, Laboratory of Parasitic Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, United States of America.
Lymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. The adult parasites impact the integrity of lymphatic vessels and damage valves, leading to a remodeling of the lymphatic system and lymphatic dilation.
View Article and Find Full Text PDFOro-facial filariasis-A systematic review of the literature.
PLoS Negl Trop Dis
November 2024
Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Introduction: Filarial pathogens are described to inhabit and affect subcutaneous and lymphatic tissues of the human host. To date, little is known on how much oral health might be affected by filarial infections, even though involvement of the oro-facial region is pathophysiologically possible. Therefore, we conducted this systematic review of the literature to help reduce the current evidence gap.
View Article and Find Full Text PDFAn unexpected parasite in bone marrow: Uncommon presentation of a common disease.
Trop Parasitol
September 2024
Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India.
Elephantiasis, also known as filariasis, is a severe public health issue in India. Microfilariae in the bone marrow smears are an unusual and incidental finding. Every peripheral blood and bone marrow aspirate smear must be screened for microfilariae in endemic areas to identify asymptomatic carriers.
View Article and Find Full Text PDFDesigning of a chimeric multiepitope vaccine against bancroftian lymphatic filariasis through immunoinformatics approaches.
PLoS One
September 2024
Department of Cellular and Molecular Biology, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh.
Article Synopsis
- The study focuses on designing a vaccine for lymphatic filariasis caused by Wuchereria bancrofti using immunoinformatics approaches to target specific proteins.
- Two vaccine candidates, V1 and V2, were developed and analyzed for their structural stability and binding affinity to immune receptors, with V1 showing better results.
- Strong immunological responses were observed in a three-dose vaccination analysis, suggesting V1's potential efficacy, but further testing is needed to fully validate its effectiveness.
Idiopathic Gingival Enlargement: A Case Report.
Cureus
July 2024
Oral and Maxillofacial Pathology, Community Health Center Rampura, Chitraduga, IND.
Article Synopsis
- Gingival enlargement (GE) is the swelling of gums due to various factors like inflammation from plaque, certain medications, systemic conditions (e.g., pregnancy, puberty), and other diseases; it can also occur without a known cause (idiopathic GE) that may have genetic links.
- This condition complicates oral hygiene, exacerbates inflammation, and negatively impacts speech, eating, appearance, and overall health.
- A case report details the successful surgical treatment of a 17-year-old girl with severe GE using gingivectomy and gingivoplasty, resulting in improved function and aesthetics after three months, with ongoing follow-up.
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