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Phlegmasia cerulea dolens is a rare manifestation of massive deep vein thrombosis with threat to limb and life. A patient with a background of ovarian malignancy in remission and pelvic radiotherapy presented with left lower limb phlegmasia cerulea dolens as a result of extensive acute left lower limb deep vein thrombosis, extending from the popliteal vein to the inferior vena cava. While initial rapid thrombolysis and left iliac vein stenting were successful, she developed significant hemorrhagic complications from her right radial intra-arterial line with compartment syndrome requiring fasciotomy.

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Case report of simultaneous phlegmasia cerulea dolens and acute limb ischemia.

Int J Surg Case Rep

December 2024

Department of Vascular surgery, University hospital of Bratislava, Faculty of Medicine - Comenius University, Slovak Republic.

Article Synopsis
  • Phlegmasia cerulea dolens (PCD) is a serious condition caused by massive deep vein thrombosis that can threaten both life and limbs, often requiring urgent treatment options such as endovascular therapy or surgical embolectomy in specific cases.
  • A patient case illustrated simultaneous PCD with acute limb ischemia, showing symptoms like abdominal pain, cyanosis, and motor deficits, leading to a successful combined surgical embolectomy to resolve the issues.
  • This report emphasizes that there are no formal guidelines for treating PCD and stresses the necessity for personalized treatment strategies and comprehensive care access.
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Venous duplications, particularly in the femoral vein, are rare anatomical variations that can complicate the clinical presentation and management of deep venous thrombosis (DVT). This case describes an elderly female who was diagnosed by her primary care physician with a left lower extremity DVT one week prior to her presentation and had been prescribed Xarelto. Despite strict adherence to therapy, her left leg pain, swelling, and discoloration worsened, prompting her hospital admission.

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A 57-year-old man presented after a fall, which resulted in acetabular and pelvic fractures. He underwent fracture fixation, which was complicated by iliac vein occlusion, leading to phlegmasia cerulea dolens. He underwent lower extremity surgical venous thrombectomy, contralateral iliac vein stent placement, and modified Palma procedure with an expanded polytetrafluoroethylene venous crossover bypass and arteriovenous fistula creation.

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Introduction: Phlegmasia cerulea dolens (PCD) is an uncommon, potentially life-threatening complication of acute deep venous thromboses that requires a timely diagnosis. The name of the condition, the visual diagnostic criteria, and the preponderance of cases in the literature referencing findings exclusively in patients with lighter skin complexions means that PCD may not be on the differential diagnosis for the patient with more melanated skin who is experiencing this time-sensitive vascular emergency.

Case Report: We describe one case of PCD in a patient with darker skin complexion and the importance of identifying clinical findings, regardless of skin color, given the paucity of reference images for PCD in darker complected patients.

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