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Preparation and application of a multiepitope fusion protein based on bioinformatics and Tandem Mass Tag-based proteomics technology.
Front Immunol
January 2025
Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, China.
Introduction: Brucellosis is a widespread zoonotic disease that poses a considerable challenge to global public health. Existing diagnostic methods for this condition, such as serological assays and bacterial culture, encounter difficulties due to their limited specificity and high operational complexity. Therefore, there is an urgent need for the development of enhanced diagnostic approaches for brucellosis.
View Article and Find Full Text PDFHow do we measure the costs, benefits, and harms of sharing data from biomedical studies? A protocol for a scoping review.
Open Res Eur
January 2025
Heidelberger Institut für Global Health, Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, 69120, Germany.
Introduction: The benefits of sharing participant-level data, including clinical or epidemiological data, genomic data, high-dimensional imaging data, or human-derived samples, from biomedical studies have been widely touted and may be taken for granted. As investments in data sharing and reuse efforts continue to grow, understanding the cost and positive and negative effects of data sharing for research participants, the general public, individual researchers, research and development, clinical practice, and public health is of growing importance. In this scoping review, we will identify and summarize existing evidence on the positive and negative impacts and costs of data sharing and how they are measured.
View Article and Find Full Text PDFIdentifying targets for antibiotic stewardship interventions in pediatric patients in Punjab, Pakistan: point prevalence surveys using AWaRe guidance.
Front Pediatr
January 2025
Department of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Introduction: Surveillance of antibiotic use is crucial for identifying targets for antibiotic stewardship programs (ASPs), particularly in pediatric populations within countries like Pakistan, where antimicrobial resistance (AMR) is escalating. This point prevalence survey (PPS) seeks to assess the patterns of antibiotic use in pediatric patients across Punjab, Pakistan, employing the WHO AWaRe classification to pinpoint targets for intervention and encourage rational antibiotic usage.
Methods: A PPS was conducted across 23 pediatric wards of 14 hospitals in the Punjab Province of Pakistan using the standardized Global-PPS methodology developed by the University of Antwerp.
OpenNavSense platform: A low-cost, open-source inertial navigation system for the evaluation of estimation algorithms.
HardwareX
March 2025
Instituto de Investigacion Astronomico y Aeroespacial Pedro Paulet, Universidad Nacional de San Agustin de Arequipa, 04000, Arequipa, Peru.
Inertial navigation systems (INS) are widely used in commercial aviation, maritime navigation, and unmanned vehicle guidance. However, these systems are often sensitive, costly, and challenging to access. To address these limitations, an open-source, low-cost platform named INS OpenNavSense has been developed.
View Article and Find Full Text PDFHata-Yanagiya physical activity calculation system: a novel global positioning system-based method for accurate estimation of oxygen consumption during walking and running.
Front Sports Act Living
January 2025
Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan.
Introduction: Marathon running has become increasingly popular among amateur athletes, many of whom maintain speeds of 8-9 km/h. However, existing methods for estimating oxygen consumption (VO) during running and walking-such as the American College of Sports Medicine (ACSM) equations and commercial activity monitors-often lack accuracy and transparency. This study introduces the Hata-Yanagiya Physical Activity Calculation (HYPAC) system, a novel approach for estimating VO using Global Positioning System (GPS) and map data.
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