AI Article Synopsis

  • Cell type-specific enhancers and housekeeping promoters play crucial roles in regulating gene transcription in mammalian cells.
  • Recent findings highlight how specific DNA sequences help connect promoters with the right enhancers, influencing how genes are expressed.
  • Additionally, these sequence features can boost the activity of many regulatory elements, enhancing their overall function.

Article Abstract

Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927642PMC
http://dx.doi.org/10.1080/21541264.2017.1378158DOI Listing

Publication Analysis

Top Keywords

housekeeping tissue-specific
4
tissue-specific cis-regulatory
4
cis-regulatory elements
4
elements recipes
4
recipes specificity
4
specificity recipes
4
recipes activity
4
activity cell
4
cell type-specific
4
type-specific housekeeping
4

Similar Publications

Cannabis Expression Atlas: a comprehensive resource for integrative analysis of Cannabis sativa L. gene expression.

Physiol Plant

December 2024

Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil.

Cannabis sativa L., a plant originating from Central Asia, is a versatile crop with applications spanning textiles, construction, pharmaceuticals, and food products. This study aimed to compile and analyze publicly available Cannabis RNA-Seq data and develop an integrated database tool to help advance Cannabis research in various topics such as fiber production, cannabinoid biosynthesis, sex determination, and plant development.

View Article and Find Full Text PDF

Expression Profiles of Housekeeping Genes and Tissue-Specific Genes in Different Tissues of Chinese Sturgeon ().

Animals (Basel)

November 2024

Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs of China, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.

The Chinese sturgeon () is an ancient, complex autooctoploid fish species that is currently facing conservation challenges throughout its distribution. To comprehensively characterize the expression profiles of genes and their associated biological functions across different tissues, we performed a transcriptome-scale gene expression analysis, focusing on housekeeping genes (HKGs), tissue-specific genes (TSGs), and co-expressed gene modules in various tissues. We collected eleven tissues to establish a transcriptomic repository, including data from Pacific Biosciences isoform sequencing (PacBio Iso-seq) and RNA sequencing (RNA-seq), and then obtained 25,434 full-length transcripts, with lengths from 307 to 9515 bp and an N50 of 3195 bp.

View Article and Find Full Text PDF

Functional characteristics and computational model of abundant hyperactive loci in the human genome.

Elife

November 2024

National Institute for Biotechnology and Information, National Library of Medicine, National Institutes of Health, Bethesda, United States.

Enhancers and promoters are classically considered to be bound by a small set of transcription factors (TFs) in a sequence-specific manner. This assumption has come under increasing skepticism as the datasets of ChIP-seq assays of TFs have expanded. In particular, high-occupancy target (HOT) loci attract hundreds of TFs with often no detectable correlation between ChIP-seq peaks and DNA-binding motif presence.

View Article and Find Full Text PDF

Expression patterns of housekeeping genes and tissue-specific genes in black goats across multiple tissues.

Sci Rep

September 2024

Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan, 528225, China.

Black goats are a significant meat breed in southern China. To investigate the expression patterns and biological functions of genes in various tissues of black goats, we analyzed housekeeping genes (HKGs), tissue-specific genes (TSGs), and hub genes (HUBGs) across 23 tissues. Additionally, we analyzed HKGs in 13 tissues under different feeding conditions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!