A concise synthesis of two scyphostatin analogues is achieved from readily available ortho-substituted phenols. Key features include an asymmetric and biomimetic hydroxylative phenol dearomatization (HPD) reaction promoted by a chiral salen-type bis(λ-iodane) reagent, followed by an in situ regio- and diastereocontrolled epoxidation.
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| http://dx.doi.org/10.1021/acs.joc.7b02366 | DOI Listing |
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