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PDZK1 gene transfer ameliorates lipopolysaccharide-induced cholestasis in rats by rescuing hepatic ABC transporters.
Biosci Biotechnol Biochem
December 2024
Central Laboratory, Department of Pharmacy, Wuhan Fourth Hospital, Wuhan, China.
Lipopolysaccharide (LPS) causes inflammatory cholestasis in sepsis. We investigated the role of PDZK1 in the repression of ABC transporters in LPS-induced cholestasis. Lentiviral gene transfer of PDZK1 to rats was conducted to explore its influence on cholestasis induced by LPS.
View Article and Find Full Text PDFStard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity.
Hepatology
December 2024
Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), CSIC; Unidad Asociada IMIM/IIBB-CSIC, Barcelona, Spain.
Article Synopsis
- - Cholestatic liver diseases (CLD) cause damage to the liver cells and can lead to fibrosis and cirrhosis due to bile acid accumulation, with STARD1 playing a potential role in this process.
- - Research found that patients with primary biliary cholangitis had higher STARD1 levels, and mice lacking STARD1 specifically in liver cells were more resistant to liver damage and inflammation associated with bile duct blockage.
- - The study suggests that targeting STARD1 could be a promising approach for treating cholestatic liver injury, as it appears to influence bile acid levels and oxidative stress in liver cells.
Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats.
Metab Brain Dis
December 2024
Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, Texas, USA.
Contradictory results have been reported about the effects of liver diseases on the blood-brain barrier (BBB) permeability to markers. For instance, both an increase and no change in the BBB permeability to BBB markers sodium fluorescein and Evans blue have been reported in experimental cholestasis induced by bile duct ligation (BDL) in rats. These contradictory effects might be due to inherent limitations of these markers and/or methodological issues.
View Article and Find Full Text PDFSwertia cincta and its main active ingredients regulate the PPAR-α pathway in anti-cholestatic liver injury.
J Ethnopharmacol
January 2025
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, China. Electronic address:
Article Synopsis
- Swertia cincta is a traditional remedy used in Yunnan, China, for treating cholestasis, although its active components and mechanisms are not well understood.
- The study aimed to investigate the therapeutic properties and active ingredients of Swertia cincta using an animal model of cholestasis induced by alpha-naphthylisothiocyanate (ANIT).
- Results revealed that specific components like gentiopicroside, loganic acid, and isoorientin help regulate various liver-related proteins and reduce inflammation, enhancing the liver's protective response against cholestatic injury.
Total Iridoid Glycosides from Franch. Alleviate Cholestasis Induced by α-Naphthyl Isothiocyanate through Activating the Farnesoid X Receptor and Inhibiting Oxidative Stress.
Int J Mol Sci
October 2024
Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
Cholestasis refers to a physiological and pathological process caused by bile acid (BA) overaccumulation inside the circulatory system and liver, leading to systemic and hepatocellular damage. Activating the farnesol X receptor (FXR) to restore BA homeostasis is a promising strategy for treating cholestasis. The objective of this research is to reveal solid evidence for the fact that the total iridoid glycosides from Franch.
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