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| http://dx.doi.org/10.4103/ijem.IJEM_539_17 | DOI Listing |
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Improved Malignancy of Colon Cancer Cells at Gene Expression Level with Constitutive Activation of the Eukaryotic Elongation Factor 2 (eEF2) Under Nutrition Deficient Conditions.
Chem Biodivers
January 2025
Biruni Universitesi, Molecular Biology and Genetics, Biruni Uni, İstanbul, TURKEY.
Regulation of protein production in response to physiological signals is achieved through precise control of Eukaryotic Elongation Factor 2 (eEF2), whose distinct translocase function is crucial for cell survival. Phosphorylation of eEF2 at its Thr56 (T56) residue inactivates this function in translation. Using genetically modified paralogue of a colon cancer cell line, HCT116 which carries a point mutation at Ser595-to-Alanine in the eEF2 gene we were able to create a constitutively active form of eEF2.
View Article and Find Full Text PDFAspirin use reduces cancer risk in betel nut chewers: a nationwide population-based cohort study.
Am J Cancer Res
December 2024
Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital Yilan 265, Taiwan.
Betel nut chewing, common in several Asian populations, is linked to increased cancer risk, including oral, esophageal, gastric, and hepatocellular carcinoma. Aspirin shows potential as a chemopreventive agent. This study investigates the association between aspirin use and cancer risk among betel nut chewers.
View Article and Find Full Text PDFSelective diet induced nutritional optic neuropathy in developmentally normal children.
Am J Ophthalmol Case Rep
March 2025
Department of Ophthalmology, Boston Children's Hospital, 300 Longwood Ave, Fegan 4, Boston, MA, 02115, USA.
Purpose: Nutritional deficiencies in developed countries are a rare but potentially intervenable cause of optic neuropathy in pediatric populations. To date, much of the literature on nutritional optic neuropathy has focused on children with developmental delay, however, a growing body of evidence supports other underreported risk factors.
Observations: We describe three pediatric patients with normal neurodevelopment, who presented with decreased vision and were subsequently found to have optic neuropathy attributed to vitamin deficiencies, predominantly vitamin B12.
Cold Plasma Treatment of Quinoa Grains: Changes in Phytic Acid, Saponin, Content, and Antioxidant Capacity.
Food Sci Nutr
January 2025
Research Center for Food Hygiene and Safety, School of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran.
The impact of atmospheric cold plasma (ACP) treatment (at 50 and 60 kV for 5 and 10 min) on nutritional (total phenolic and flavonoids contents, antioxidant capacity, and TBARs) and antinutritional (saponin and phytic acid) characteristics of quinoa grains has been investigated at this study. Results indicated that ACP treatment is significantly effective to reduce the antinutritional compounds compared with the control sample ( ≤ 0.05), among which S (i.
View Article and Find Full Text PDFCardiovascular diseases (CVDs) remain one of the leading causes of morbidity and mortality worldwide. In recent years, the potential role of dietary interventions in preventing and managing CVDs has gained significant attention. Among these dietary components, walnuts ( L.
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