Humans and rodents differ in how they carry out X inactivation (XI), the mammalian method to compensate for the different number of X chromosomes in males and females. Evolutionary changes in staging embryogenesis and in mutations within the XI center alter the process among mammals. The mouse model of XI is predicated on X counting and subsequently choosing the X to 'inactivate'. However, new evidence suggests that humans initiate XI by protecting one X in both sexes from inactivation by XIST, the noncoding RNA that silences the inactive X. This opinion article explores the question of how the active X is protected from silencing by its own Xist locus, and the possibility of different solutions for mouse and human.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tig.2017.09.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Agronomic characteristics, mineral nutrient content, antioxidant capacity, biochemical composition, and fatty acid profile of Iranian pistachio (Pistacia vera L.) cultivars.
BMC Plant Biol
January 2025
Republic of Türkiye, Ministry of Agriculture and Forestry, Hatay Olive Research Institute Directorate, General Directorate of Agricultural Research and Policies, Hassa Station, Hassa, Hatay, 31700, Türkiye.
Background: Pistachio (Pistacia vera L.) nuts are among the most popular nuts. The pistachio cultivars are tolerant to both drought and salinity, which is why they are extensively grown in the arid, saline, and hot regions of the Middle East, Mediterranean countries, and the United States.
View Article and Find Full Text PDFValidation of an Aerobic Fitness Questionnaire to estimate VO peak in a cohort of adult cardiac patients - Is it enough?
Rev Port Cardiol
January 2025
Cardiology Department, Santa Cruz Hospital, Lisbon, Portugal; Cardiac Rehabilitation Unit, Santa Cruz Hospital, Lisbon, Portugal.
Introduction And Objectives: Cardiopulmonary exercise testing (CPET) is the gold standard for quantifying aerobic functional capacity, yet it is costly and not widely available. The CLINIMEX Aerobic Fitness Questionnaire (C-AFQ) may be a practical alternative as it estimates oxygen consumption at peak exercise (VO peak) based on patients' responses to a list of activities with known energy requirements. However, its applicability in cardiac patients is unclear and has not yet been studied.
View Article and Find Full Text PDFA Mobile Health Intervention to Support Collaborative Decision-Making in Mental Health Care: Development and Usability.
JMIR Form Res
January 2025
Early Intervention in Psychosis Advisory Unit for South-East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Background: Shared decision-making between clinicians and service users is crucial in mental health care. One significant barrier to achieving this goal is the lack of user-centered services. Integrating digital tools into mental health services holds promise for addressing some of these challenges.
View Article and Find Full Text PDFBurnout in Military Orthopedic Surgeons: A Multicenter, Cross-Sectional Study.
Mil Med
January 2025
Department of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.
Background: High rates of burnout are prevalent in U.S. physicians with evidence that the rates are increasing.
View Article and Find Full Text PDFGut decontamination in the poisoned patient.
Br J Clin Pharmacol
January 2025
Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Poisoning management includes gastrointestinal decontamination strategies to decrease the burden of poison entering the body and change the expected severe toxicity expected to a less toxic, more favourable outcome. Common modalities are orogastric lavage, oral-activated charcoal and whole-bowel irrigation. Endoscopic retrieval and laparotomy are rare options reserved for severe ingestions and body packers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!