The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed. A negative-pressure dressing can be easily and rapidly applied to obtain a temporary closure between surgical stages. While negative pressure wound therapy (NPWT) has clear indications in the management of chronic wounds, its applications in the acute setting in victims of polytrauma are uneven. We conducted a review of the current clinical literature to evaluate the role of NPWT in this field, which points out that the negative pressure, applied immediately after the first debridement, seems to be an optimal bridge to the final reconstruction up to 7 days.
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http://dx.doi.org/10.1055/s-0037-1606542 | DOI Listing |
Alzheimers Dement
December 2024
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Chong Qing, China.
Background: Alzheimer's disease (AD) frequently coexists with cerebral small vessel disease (CSVD) is common in the aging population, yet the underlying mechanisms are not yet fully understood. Both long-term blood pressure variability (BPV) and plasma neurofilament light (PNFL) were identified as potential biomarkers for AD and CSVD. This study aims to understand the mechanisms of comorbidity between AD and CSVD by investigating the associations among BPV, PNFL, and comorbidity.
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December 2024
West China Hospital of Sichuan University, Chengdu, China.
Background: Idiopathic normal pressure hydrocephalus (iNPH) is highly prevalent among elderly individuals, and there is a strong correlation between telomere length and biological aging. However, there is limited evidence to elucidate the relationship between telomere length and iNPH. This study aimed to investigate the associations between telomere length and iNPH using the Mendelian randomization (MR) method.
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December 2024
The Translational Genomics Research Institute (TGen- an Affiliate of City of Hope), Phoenix, AZ, USA.
Background: Alzheimer's Disease (AD) is characterized by cognitive decline due to synaptic loss and neuron death, with amyloid-β plaques and neurofibrillary tau tangles as key pathological hallmarks. Although genetics account for about 70% of AD risk, modifiable factors also significantly contribute to AD and dementia onset and AD-resilience. Utilizing the All of Us (AoU) cohort, this study explores the relationship between clinical conditions, quantitative phenotypes (including lab tests and anthropometric measurements), and AD risk, shedding light on potential preventative measures.
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December 2024
National Institute on Aging/National Institutes of Health (NIA/NIH), Baltimore, MD, USA.
Background: Early vascular aging (EVA), manifesting as increases in central arterial stiffness and BP, is associated with cognitive impairment in humans. EVA and cognitive impairment occurs in Dahl salt-sensitive (DSS) rats consuming a normal salt (NS) diet with an advancing age. Quercetin (QRC), a flavonoid with anti-oxidant, anti-inflammatory and senolytic properties, previously shown to reduce salt-sensitive hypertension in DSS.
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December 2024
University of Calgary, Calgary, AB, Canada.
Background: Mild behavioral impairment (MBI) is a syndrome that leverages neuropsychiatric symptoms that emerge in later-life, and which persist, to identify individuals at high-risk for incident dementia. Attendant with MBI are changes in quality of life (QoL), which can present concurrent with the onset of cognitive decline or even before. Obtaining information from participants and study partners can provide a broader overview of health and QoL.
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