Background: IL-31 is a cytokine that is believed to play an important role in atopic dermatitis (AD). IL-31 levels positively correlate with disease severity in children with AD. Currently, there is no study that has investigated such a correlation in atopic dogs.
Hypothesis/objective: The purpose of this study was to evaluate the correlation between IL-31 serum levels and severity of dermatitis. It was hypothesized that a positive correlation exists between severity of AD and circulating levels of IL-31.
Animals: Sixteen atopic beagles experimentally sensitized to house dust mites.
Methods: Atopic beagles were exposed to dust mites epicutaneously twice weekly for four weeks. Severity of dermatitis was scored by the Canine Atopic Dermatitis and Extent Severity Index, 3 iteration (CADESI-03) on days 0 and 28. Blood samples were taken on days 0 and 28 to measure serum IL-31 using a commercially available ELISA.
Results: Correlation between CADESI-03 scores and serum IL-31 levels was not detected on day 0 (Pearson, r = -0.2609, P = 0.3291). After flare-up of dermatitis was induced with allergen exposure, a significant positive correlation was detected between serum IL-31 and CADESI-03 on Day 28 (r = 0.6738, P = 0.004).
Conclusions And Clinical Importance: Positive correlation was detected in active disease between severity of dermatitis and circulating levels of IL-31. Additional studies are needed to investigate this correlation in other breeds of dogs and to test whether circulating levels of IL-31 may predict clinical response to biological agents aimed at IL-31.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/vde.12500 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive cytokines of omalizumab in the treatment of chronic spontaneous urticaria.
Cytokine
January 2025
Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.. Electronic address:
Background: Omalizumab, an anti-IgE biological agent, is commonly prescribed as a second-line therapy for Chronic Spontaneous Urticaria (CSU). However, there is a lack of biomarkers to predict which CSU patients will respond favorably to omalizumab.
Objective: Our study aims to identify cytokine markers associated with the efficacy of omalizumab in treating CSU.
Comparative effectiveness of upadacitinib versus dupilumab for moderate-to-severe atopic dermatitis: A retrospective cohort study.
Int Immunopharmacol
December 2024
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong 510095, PR China. Electronic address:
Article Synopsis
- A retrospective study was conducted to compare the effectiveness and safety of Upadacitinib and Dupilumab in treating patients with moderate to severe atopic dermatitis (AD) in real-world settings.
- The study involved 87 patients over 12 weeks, showing that Upadacitinib led to significantly greater improvements in key skin and symptom scores compared to Dupilumab, especially noticeable by week 4.
- While Upadacitinib was linked with more adverse events, no serious complications were reported, and overall, both treatments were found to be effective, with Upadacitinib demonstrating quicker results.
Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations.
Cent Eur J Immunol
July 2024
Department of Medicine, Microbiology/Immunology, College of Medicine, University of Sulaimani, Iraq.
Introduction: In adult-onset asthma, two major endotypes have been proposed: T2 with eosinophilia and non-T2 characterised by neutrophils and interleukin (IL)-17. The objective of the study was to examine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a focus on differentiating between viral and non-viral triggers.
Material And Methods: Forty-nine patients with asthma, admitted for exacerbations, and 51 healthy controls (HCs) were recruited.
Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure.
World J Clin Cases
September 2024
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region, China.
Liver failure (LF) is prevalent in China and is characterized by complex pathogenesis, challenging clinical management, poor prognosis, and rising incidence and mortality rates. The immune status is an important factor affecting LF prognosis. Interleukins (Ils) are a type of cytokine that act and interact with multiple cells, including immune cells.
View Article and Find Full Text PDFInterleukin 31 in vitiligo patients with and without pruritus.
Acta Dermatovenerol Alp Pannonica Adriat
September 2024
Department of Dermatology, STDs, and Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Article Synopsis
- Vitiligo is a skin condition that results in loss of pigment due to the destruction of melanocytes, and this study investigates the role of Interleukin (IL)-31 in relation to pruritus (itchiness) and skin inflammation in vitiligo patients.
- The study involved 90 participants divided into three groups: those with vitiligo, those with vitiligo and pruritus, and healthy controls, measuring serum IL-31 levels using ELISA.
- Results indicated that IL-31 levels were highest in vitiligo patients with pruritus, showing significant correlations with disease activity, lesion extent, and itchiness, suggesting IL-31 could be important for early diagnosis of vitiligo.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!