Drug-induced acute pancreatitis is a rare cause of pancreatitis. We present a case of pancreatitis caused by pazopanib, a tyrosine kinase inhibitor used in the treatment of renal cell carcinoma. A 57-year-old male with no risk factors for pancreatitis and a past medical history of renal cell carcinoma who was being treated with pazopanib presented with epigastric pain with radiation to the back. Lipase was elevated to 7,960 units/L. Pazopanib was discontinued on arrival and his lipase levels decreased from 7,960 to 3,380 units/L one day after discontinuation. Abdominal pain resolved and patient tolerated a diet. This case illustrates the importance that medical professionals should be aware of acute pancreatitis as a rare but severe side effect of pazopanib and therefore should monitor and educate their patients accordingly.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624657 | PMC |
| http://dx.doi.org/10.14740/wjon1006e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A case of recurrent pancreatitis was diagnosed as intraductal papillary mucinous neoplasm of the pancreas through MRCP and EUS.
Dig Liver Dis
March 2025
Department of Gastroenterology, Fengdu People's Hospital, Chongqing 408200, China. Electronic address:
European Consensus on Malabsorption-UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN: Part 2: Screening, Special Populations, Nutritional Goals, Supportive Care, Primary Care Perspective.
United European Gastroenterol J
March 2025
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy.
Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac disease (CD) and other enteropathies, lactase deficiency, small intestinal bacterial overgrowth (SIBO), autoimmune atrophic gastritis, Crohn's disease, and gastric or small bowel resections. Early recognition of malabsorption is key for tailoring a proper diagnostic work-up for identifying the cause of malabsorption.
View Article and Find Full Text PDFUnsedated emergent ERCP is feasible and efficient for acute cholangitis in old patients over 80 years.
Surg Endosc
March 2025
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Acute cholangitis in elderly patients poses unique challenges due to comorbidities and frailty, necessitating timely intervention. This study evaluates the feasibility and efficiency of unsedated emergent endoscopic retrograde cholangiopancreatography (ERCP) in patients over 80 years with acute cholangitis.
Methods: A retrospective analysis of elderly patients (≥ 80 years) presenting with acute cholangitis who underwent unsedated emergent ERCP between January 2020 and December 2023 was conducted.
Acute intestinal obstruction due to duodenal metastasis of laryngeal squamous cell carcinoma: A CARE case report.
Eur Ann Otorhinolaryngol Head Neck Dis
March 2025
Service de chirurgie digestive, CHU Saint-Etienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
Objective: To report a case of duodenal metastasis of laryngeal squamous cell carcinoma revealed by acute intestinal obstruction.
Case Report: A 55-year-old male was initially treated for cT4N1M0 laryngeal squamous cell carcinoma, with total laryngectomy, bilateral neck dissection, total thyroidectomy and pectoralis major flap. Subsequently, he received radiotherapy and chemotherapy.
Lactated Ringer's solution versus saline fluid resuscitation for reducing PROGRESSION TO moderate-to-severe acute pancreatitis: a systematic review and meta-analysis.
Int J Surg
March 2025
Department of Hepatobiliary surgery, The Affiliated Hospital of Southwest Medical University, Lu Zhou, China.
Background: Fluid resuscitation represents a pivotal early therapeutic intervention in the management of acute pancreatitis (AP), yet a consensus on the optimal fluid type remains elusive. The present study endeavors to elucidate the differential effects of lactated Ringer's solution (LR) and normal saline (NS) in the initial treatment of AP.
Methods: A comprehensive literature search was conducted through the PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases, spanning from inception until July 2024.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!