Obstructive sleep apnea (OSA) is a common disease with high morbidity and related mortality. Narrowing and collapse of the pharyngeal airway during sleep characterize the disease, resulting in a decrease (hypopnea) or a complete cessation (apnea) of oronasal airflow. Upper airway stimulation (UAS), using electrical neurostimulation of the hypoglossal nerve (n. XII) synchronized with ventilation, is a novel, evolving treatment option. UAS was found to be an effective treatment in CPAP-intolerant patients. The treatment success is partly due to the strict selection of the patients, based on previous findings. Furthermore, post-operative follow-up is needed in order to maintain or improve treatment outcome. Therefore, a clinical pathway, which provides structure and standardization, is crucial. In this paper, the aim is to discuss the technical aspects of UAS therapy and to describe a clinical pathway to organize the care process of UAS for OSA in a structured and standardized way.
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http://dx.doi.org/10.3389/fnins.2017.00523 | DOI Listing |
PLoS One
December 2024
School of Business Administration, Shandong University of Finance and Economics, Jinan, Shandong, China.
In recent years, China has significantly increased its global competitiveness in digital technologies, emphasizing the importance of the digital economy during the high-quality development stage. The question of how firms in traditional industries can achieve digital transformation, which is critical for participating in the digital economy, is still understudied. Using the ability-motivation-opportunity (AMO) framework, this research developed a model and identified six factors' ability, motivation, and opportunity dimensions.
View Article and Find Full Text PDFEnviron Health Perspect
December 2024
Public and Occupational Health, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Background: Climate change is the 21st century's biggest global health threat, endangering health care systems worldwide. Health care systems, and hospital care in particular, are also major contributors to greenhouse gas emissions.
Objectives: This study used a systematic search and screening process to review the carbon footprint of hospital services and care pathways, exploring key contributing factors and outlining the rationale for chosen services and care pathways in the studies.
Neuroradiology
December 2024
Department of Neuroradiology, Istituto Giannina Gaslini, Genoa, Italy.
Various space occupying lesions can arise in the orbit, ranging from developmental anomalies to malignancies, and many of the diseases occurring in children are different from the pathologies in the adult population. As the clinical presentation is frequently nonspecific, radiologic evaluation is essential for lesion detection and characterization as well as patient management. While orbital masses may in some cases involve multiple compartments, a simple compartmental approach is the key for the diagnosis on imaging studies, and MRI is the modality of choice.
View Article and Find Full Text PDFGeroscience
December 2024
Center for Aging Biomedicine, College of Life Sciences, National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, Hunan Normal University, 36 Lushan Road, Changsha, 410081, Hunan, China.
Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans (C.
View Article and Find Full Text PDFJ Mol Histol
December 2024
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, P.O.Box 16635-148, Tehran, Iran.
Embryonic development during the preimplantation stages is highly sensitive and critically dependent on the reception of signaling cues. The precise coordination of diverse pathways and signaling factors is essential for successful embryonic progression. Even minor disruptions in these factors can result in physiological dysfunction, fetal malformations, or embryonic arrest.
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