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Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.
Eur Heart J
January 2025
Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, White City Campus, 90 Wood Lane, London W12 0BZ, UK.
Background And Aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear.
Methods: Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD.
Prevalence of traditional cardiovascular risk factors in high-risk Kyrgyzstan population as compared to Indians - An Indo-Kyrgyz cardiometabolic study.
J Family Med Prim Care
December 2024
Department of Orthopedics, B.J Medical College, Ahmedabad, Gujarat, India.
Background: Cardiovascular diseases (CVDs) are one of the most prevalent causes of mortality worldwide, especially significant in low- and middle-income countries. Kyrgyzstan and India represent such nations that face a huge burden of CVD-related deaths globally. Understanding the prevalence of traditional cardiovascular risk factors (CVRFs) in these populations is critical for effective prevention and management strategies.
View Article and Find Full Text PDFSex-Specific Difference in Health-Related Altitude-Effects and Their Prevention by Acetazolamide. Data from a Randomized Controlled Trial.
High Alt Med Biol
January 2025
Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland.
Häfliger, Alina, Aline Buergin, Laura C. Mayer, Maamed Mademilov, Mona Lichtblau, Talantbek Sooronbaev, Silvia Ulrich, Konrad E. Bloch, and Michael Furian.
View Article and Find Full Text PDFRight ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials.
Open Heart
January 2025
Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland
Background: Hypoxic pulmonary vasoconstriction leads to an increase in pulmonary artery pressure (PAP) and potentially right heart failure in healthy individuals and patients with respiratory diseases. Previous studies in patients with chronic obstructive pulmonary disease (COPD) exposed to hypobaric hypoxia have shown an increase in PAP, while traditional echocardiographic parameters revealed only minimal changes at high altitude. Speckle-tracking-derived analysis is potentially more sensitive to assess right ventricular (RV) function and we used this method to investigate the impact on RV function of patients with COPD ascending to high altitude and compared the results with the traditional echocardiographic parameters.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed global, regional, and national trends in injury burden and identified risk factors contributing to injuries using data from the GBD 2019.
- In 2019, there were approximately 713.9 million injury incidents and 4.3 million injury-related deaths globally, with low bone mineral density emerging as the leading risk factor.
- The findings emphasize the need for effective global injury prevention policies by highlighting the persistent impact of injuries on global health.
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