Traumatic brain injury (TBI) afflicts veterans, active duty service members and the civilian community. An estimated 5.3 million US men, women, and children live with a permanent TBI-related disability. There is no cure for TBI, and the discovery of new and effective treatments is complicated by the fact that TBI is multifaceted and varies from individual to individual. Due to its established research centers, wealth of veteran health data, and commitment to veteran health, the VA should be considered a natural leader for expanded TBI research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/02699052.2017.1359335 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Burnout Syndrome in forensic medicine and its association with vicarious trauma, posttraumatic stress syndrome and occupational stress.
Int J Legal Med
January 2025
Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, 550169, Romania.
The burnout phenomenon is a subject of considerable interest due to its impact on both employee well-being and scientific inquiry. Workplace factors, both intrinsic and extrinsic, play a pivotal role in its development, often leading to job dissatisfaction and heightened burnout risk. Chronic stress and burnout induce significant dysregulation in the autonomic nervous system and hormonal pathways, alongside structural brain changes.
View Article and Find Full Text PDFPotassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells.
Cells
January 2025
Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06123 Perugia, Italy.
Article Synopsis
- Amniotic fluid contains stem cells (AF-SCs) that have potential uses in regenerative medicine for treating various injuries and diseases.
- When exposed to basic Fibroblast Growth Factor (bFGF), AF-SCs show the ability to survive and migrate in a rat brain model, resembling characteristics of neuronal/glial progenitor cells.
- The study employs electrophysiological techniques to identify specific potassium currents in AF-SCs and confirms that histamine can influence calcium dynamics and potassium current activation in these cells.
Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.
Cells
December 2024
Institute of Anaesthesiologic Pathophysiology and Process Development, University Hospital Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
Article Synopsis
- Traumatic brain injury (TBI) is a leading cause of death, complicating the development of effective therapies due to the unique nature of each injury.
- Clinical questions regarding the benefits of measuring intracranial pressure, cerebral perfusion pressure, and surgical interventions remain largely unanswered.
- This study focused on acute subdural hematoma in a porcine model to better understand secondary brain injury and the effects of different injury patterns on outcomes, highlighting the need for comprehensive models to improve TBI treatment translation.
Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.
Ann Neurol
January 2025
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Article Synopsis
- About 20% of familial ALS cases are linked to mutations in the SOD1 gene, and traumatic brain injury (TBI) is identified as a possible risk factor.
- Researchers studied the effects of repetitive TBI on ALS progression in SOD1 mouse models and the role of Sarm1, a regulator of axonal degeneration.
- Results showed that TBI worsened ALS symptoms and disease progression, but losing Sarm1 helped improve outcomes and reduced nerve damage, indicating potential for SARM1-targeted treatments.
The canine blood-brain barrier in health and disease: focus on brain protection.
Vet Q
December 2025
Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!