Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms. In this chapter, we introduce four representative methods to reconstruct haplotypes from unphased genotype data, two of them are for unrelated individuals and the other two are for families.
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| http://dx.doi.org/10.1007/978-1-4939-7274-6_23 | DOI Listing |
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