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Development and Optimization of Dispersible Tablet of with Improved Functionality for Memory Enhancement. | LitMetric
Introduction : The is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people.Objective : Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets.Materials And Methods : The inclusion complex of and β-cyclodextrin was prepared in different molar ratios of by Co-precipitation method. Phase solubility study was conducted to evaluate the effect of β-cyclodextrin on aqueous solubility of Bacoside A. The characterization was determined by Fourier transformation infrared spectroscopy (FTIR),Differential scanning calorimetry (DSC) and X-ray diffraction study (XRD).Crospovidone and croscarmallose sodium were used as super disintigrant. The 3 full factorial design was adopted to investigate the influence of two superdisintegrants on the wetting time and disntegration time of the tablets.Conclusion : The result revels that molar ratio (1:4) of inclusion complex enhance 3-fold solubility. Full factorial design was successfully employed for the optimization of dispersible tablet of . The short-term accelerated stability study confirmed that high stability of in inclusion complex.
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