Embryonic germ cells are formed from embryonic progenitors through a highly complex differentiation process, recapitulation of which has proved challenging. Two new studies in report culture conditions for embryonic stem cell‐derived primordial germ cell‐like cells (PGCLCs) that enable global DNA demethylation (Ohta , 2017), and subsequent initiation of meiosis (Miyauchi , 2017), allowing future manipulations to elucidate mechanisms driving germ line differentiation.
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| http://dx.doi.org/10.15252/embj.201798101 | DOI Listing |
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