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The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome. | LitMetric

AI Article Synopsis

  • The study aimed to explore the connection between irisin, RBP-4, adiponectin, and proinflammatory factors associated with insulin resistance in metabolic syndrome (MetS).
  • Conducted on 180 participants, the research found that levels of hsCRP, PTX-3, IL-33, irisin, and RBP-4 were higher, while adiponectin levels were lower in individuals with MetS compared to controls.
  • The results suggested that irisin and adiponectin could play a role in the development of MetS and highlight the need for further research to understand the underlying mechanisms.

Article Abstract

Objective: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS).

Subjects And Methods: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits.

Results: While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL.

Conclusions: Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522070PMC
http://dx.doi.org/10.1590/2359-3997000000289DOI Listing

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