AI Article Synopsis
- The text reviews the pros and cons of viral and non-viral vectors used for gene delivery.
- Advances in gene delivery methods, such as self-deleting retroviral vectors and chimeric viruses, are discussed alongside systems that can inhibit gene expression like antisense oligonucleotides.
- The application of these gene delivery systems in animal studies and clinical trials focused on gastrointestinal disorders is also highlighted.
Article Abstract
The advantages and disadvantages of viral and non-viral vectors for gene delivery are reviewed. Advances in systems for introduction of new gene expression are described, including self-deleting retroviral transfer vectors, chimeric viruses and chimeric oligonucleotides. Systems for inhibition of gene expression are also discussed including antisense oligonucleotides, ribozymes and dominant-negative genes. Examples of the use of these systems in animal models and clinical trials for gastrointestinal disorders are discussed.
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| http://dx.doi.org/10.1111/j.1440-1746.1998.tb01867.x | DOI Listing |
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