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LC-HRMS screening procedure for the detection of 11 different classes of prohibited substances in dried urine spots for doping control purposes.
Anal Bioanal Chem
January 2025
Doping Control Laboratory, Department of Diagnostic Sciences, Ghent University, Block B, Ottergemsesteenweg 460, BE-9000, Ghent, Belgium.
Dried urine spots have recently been proposed as an alternative matrix in the anti-doping field. Drying urine may open the opportunity to limit microbial and thermal degradation of the prohibited substances during transportation to the anti-doping laboratories without the need for refrigeration or freezing. In this study, a multi-targeted initial testing procedure was developed for the determination of 237 prohibited drugs/metabolites from 11 different classes in dried urine spots.
View Article and Find Full Text PDFBackground: While subject coenrollment into multiple trials is desirable, thoughtful consideration is required to avoid compromising each trial's scientific integrity.
Objective: We developed a Decision-Making Grid (GRID) to help investigators determine whether a clinical trial is compatible with a second clinical trial, thus allowing coenrollment, or if it should be considered competing, prohibiting coenrollment.
Methods: The GRID evaluates 21 elements across 4 domains: Scientific Integrity, Data Interpretation, Feasibility/Burden, and Additional Considerations.
Real-Time Dyson-Expansion Scheme: Efficient Inclusion of Dynamical Correlations in Nonequilibrium Spectral Properties.
Phys Rev Lett
November 2024
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93117, USA and Department of Materials, University of California, Santa Barbara, Santa Barbara 93117, USA.
Time-resolved photoemission spectroscopy is the key technique to probe the real-time nonequilibrium dynamics of electronic states. Theoretical predictions of the time dependent spectral function for realistic systems is however, a challenge. Employing the Kadanoff-Baym equations to find this quantity results in a cubic scaling in the total number of time steps, quickly becoming prohibitive and often fail quantitatively and even qualitatively.
View Article and Find Full Text PDFAs life expectancy rises, so too does the prevalence of neurodegenerative diseases. Neurodegeneration causes progressive regional brain atrophy, typically initiating prior to symptom onset. Researchers measure the impact of potential treatments on atrophy in mouse models to assess their effectiveness.
View Article and Find Full Text PDFThe more fun, the more dangerous: The nutritional quality of foods with child-directed marketing.
Food Res Int
December 2024
Food Labeling Observatory, Nutrition and Food Service Research Center (CPPNAC), Federal University of São Paulo (UNIFESP), Santos, SP, Brazil. Electronic address:
Article Synopsis
- The study analyzed the nutritional quality of foods and beverages that employ child-directed marketing on their labels in Brazil, assessing data from over 8,900 products collected before new labeling laws were introduced.
- More than 10% of the products used child-targeted marketing, with over half having high sugar and fat content, indicating poor overall nutritional quality.
- The findings showed low agreement among different nutritional classification systems, with a recommendation for stricter regulations to limit marketing unhealthy foods to children.
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