By immunohistochemistry, neuropeptide Y (NPY) localizes to neurons in the rat pterygopalatine ganglion. These cells also are intensely or moderately reactive with acetylcholinesterase histochemistry. In contrast, both tyrosine hydroxylase immunohistochemistry and glyoxylic acid-induced fluorescence for catecholamines stain smaller clustered cells, similar in appearance to small intensely fluorescent (SIF) cells and clearly distinct from the NPY-immunoreactive cells. By reverse phase high-performance liquid chromatography, the NPY-immunoreactive material in the rat pterygopalatine ganglion migrates as a single peak characteristic of the peptide. We conclude that NPY-containing cholinergic cells are present in this classical parasympathetic ganglion. NPY-like immunoreactive neurons similarly occur in the pterygopalatine ganglion of the guinea pig.
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