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Real-world performance of a clinical droplet digital polymerase chain reaction assay for non-invasive foetal blood group and platelet antigen genotyping of alloimmunized pregnant women with antibodies directed against RhD, RhE, Rhc, RhC, K1, HPA-1a or HPA-5b: A 1-year experience.
Vox Sang
December 2024
Clinical Laboratory Advise, Sanquin Diagnostic Services, Sanquin, Amsterdam, The Netherlands.
Background And Objectives: To test the performance of a new droplet digital polymerase chain reaction (ddPCR) non-invasive foetal blood group and platelet antigen genotyping assay in the setting of a Dutch reference laboratory for foetal blood group and platelet antigen genotyping. Our population comprised 229 consecutive alloimmunized pregnant women who presented between April 2022 and March 2023 with 250 requests for non-invasive foetal RHD, RHE, RHc, RHC, K1, HPA-1a or HPA-5b blood group and platelet antigen genotyping.
Materials And Methods: Samples were genotyped for blood group and platelet antigen alleles along with methylated RASSF1a (mRASSF1a) and sex-determining region of Y (SRY) and DYS14 as positive foetal controls.
Aging negatively affects postoperative recovery of biomechanical strength through decreased recruitment of Scx/Sox9 enthesis-related progenitors after rotator cuff repair in rats.
J Shoulder Elbow Surg
December 2024
Department of Orthopedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:
Background: Although older adult patients have a higher retear rate after rotator cuff (RC) repair, the influence of aging on the healing process remains unclear. During mouse enthesis development, a multipotent progenitor co-expressing scleraxis (Scx) and SRY-box 9 (Sox9) contributes to enthesis formation. Scx/Sox9 cells may act as enthesis progenitors even during postnatal healing, and their number decreases with maturation.
View Article and Find Full Text PDFDevelopment of a PCR-based method to identify fetal sex during IVF cycles.
Zygote
August 2024
Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.
One of the most recognizable cases of preimplantation genetic diagnosis (PGD) is X-linked diseases. Diagnosis of fetal sex is essential for couples who are known to be at risk of some X-linked disorders. The objective of this study was to discriminate between female (XX) and male (XY) embryos by detecting sex chromosomes-specific sequences in spent culture medium and comparing these results to PGD/CGH array results.
View Article and Find Full Text PDFCirc_0084653 promotes the tumor progression and immune escape in triple-negative breast cancer via the deubiquitination of MYC and upregulation of SOX5.
Int J Biol Macromol
September 2024
Department of Breast Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin Medical University, Ministry of Education, Tianjin 300060, China; National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China; Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin 300060, China. Electronic address:
Article Synopsis
- Circular RNAs (circRNAs) like circ_0084653, which arises from the COPS5 gene, are increasingly recognized for their role in triple-negative breast cancer (TNBC) and are shown to be upregulated in TNBC cells.* -
- Knockdown of COPS5 resulted in decreased cell proliferation, invasion, and other cancer traits, while circ_0084653 silence also inhibited TNBC progression, indicating a regulatory relationship between these molecules and cancer development.* -
- circ_0084653 enhances TNBC by deubiquitinating the MYC protein through USP36 recruitment and acting as a sponge for miR-1323, subsequently increasing the expression of the SOX5 gene, which
Quantitative Biomarkers, Genomic Assays, and Demographics Associated with Breast-Conserving Surgery Following Neoadjuvant Therapy in Early-Stage, Hormone Receptor-Positive, HER-Negative Breast Cancer.
Ann Surg Oncol
December 2024
Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Background: Given increased neoadjuvant therapy use in early-stage, hormone receptor (HR)-positive/HER2-negative breast cancer, we sought to quantify likelihood of breast-conserving surgery (BCS) after neoadjuvant chemotherapy (NACT) or endocrine therapy (NET) as a function of ER%/PR%/Ki-67%, 21-gene recurrence scores (RS), or 70-gene risk groups.
Methods: We analyzed the 2010-2020 National Cancer Database. Surgery was categorized as "mastectomy/BCS.
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