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Host metabolism balances microbial regulation of bile acid signalling.
Nature
January 2025
Department of Chemistry and Chemical Biology, Boyce Thompson Institute, Cornell University, Ithaca, NY, USA.
Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development, metabolism, immune responses and cognitive function. However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear. Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine (BA-MCY) conjugates that are abundant in the intestine and dependent on vanin 1 (VNN1), a pantetheinase highly expressed in intestinal tissues.
View Article and Find Full Text PDFPotential New Expression Biomarkers for Anorexia Nervosa.
Am J Med Genet B Neuropsychiatr Genet
December 2024
Service de Médecine Génomique des maladies de système et d'organe, Hôpital Cochin, Assistance Publique, Centre Université de Paris Cité, Paris, France.
Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta-analysis of genome-wide association studies on AN identified independent risk-conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated. To investigate AN, we performed transcriptome profiling in peripheral blood mononuclear cells from 15 AN patients and 15 healthy controls.
View Article and Find Full Text PDFExpression of SIRT6 and VNN1 in children with primary nephrotic syndrome and their correlation with acute kidney injury.
Am J Transl Res
September 2024
Department of Laboratory, Shanxi University of Traditional Chinese Medicine Affiliated Hospital Taiyuan 030024, Shanxi, China.
Objective: To explore the diagnostic and prognostic values of Sirtuin 6 (SIRT6) and Vanin-1 (VNN1) in peripheral blood monocytes of children with primary nephrotic syndrome (PNS) and their correlation with acute kidney injury (AKI).
Methods: A retrospective analysis was conducted on 101 children (observation group) diagnosed with PNS and treated at the Shanxi University of Traditional Chinese Medicine Affiliated Hospital from December 2021 to December 2023. These children were categorized into two groups: the AKI group (n=35) and the non-AKI group (n=66), based on the presence of AKI.
Gene Expression and Polymorphisms Associated with Chicken Carcass Traits.
Animals (Basel)
June 2024
State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
This study aimed to investigate the association between hepatic expression and carcass traits in Mahuang chickens as well as to identify polymorphisms in the upstream and downstream regions of that could potentially be associated with these carcass traits. The study revealed that expression levels in liver correlated with various carcass traits such as dressed weight, eviscerated weight, and abdominal fat weight. A total of 39 polymorphic sites were identified, among which 23 were found to be associated with 15 different carcass traits.
View Article and Find Full Text PDFVanin-2 is expressed in peripheral blood T cells and upregulated in patients with systemic lupus erythematosus.
J Leukoc Biol
November 2024
Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, School of Basic Medical Sciences, Peking University Health Science Center, No. 38, Xuyuan Road, Beijing 100191, China.
Members of the vanin gene family include VNN1, VNN2, and VNN3 in humans. Although the functions of vanins have been widely examined in myeloid cells, their expression and functions have not been clarified in T lymphocytes. This study aimed to elucidate the significance of Vanin-2 (VNN2) on human peripheral blood T lymphocytes and study its expression in systemic lupus erythematosus (SLE).
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