Rare diseases, either of genetic or epigenetic origin, either proliferative or degenerative, are hard to be studied credibly, because of sparse prevalence, thus, small sampling. In addition, biological or translational experimentation either with animal models, or in vitro studies share small sampling-often due to lack of financial support or due to mannered and costly techniques. Pilot or feasibility studies been performed, before expensive clinical trials are decided, focus on small samples. Small Samples Evaluator (SSEv) is a useful tool based on a modification of survival curves. The technique can be applied to repeated measures, as well as to case-control or cross-sectional designed studies. A web-based application of SSEv is created and presented herein. The application is freely accessible at: https://ssev.eu .
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