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Discrimination of supramolecular chirality using a protein nanopore. | LitMetric

Discrimination of supramolecular chirality using a protein nanopore.

Chem Sci

EaStCHEM School of Chemistry , University of Edinburgh, Joseph Black Building, David Brewster Road , Edinburgh EH9 3FJ , UK . Email:

Published: July 2017

AI Article Synopsis

Article Abstract

Supramolecular chirality may emerge from self-assembly processes to yield architectures that differ only in the topological arrangement of their constituent parts. Since the properties of the resulting enantiomeric assemblies are identical, purification and characterisation can be challenging. Here, we have examined the hypothesis that the intrinsic chirality of a protein nanopore can be exploited to detect supramolecular chirality. Transient blockages in the ion current flowing through a single membrane-spanning α-haemolysin nanopore were shown to discriminate between ML tetrahedral coordination cages of opposing chiralities. The single-molecule nature of the approach facilitated direct access to the rates of association and dissociation with the nanopore, which allowed the concentrations of the enantiomeric supramolecular assemblies to be determined . Thus, we have established that a protein nanopore can be used to discriminate the chiral topologies of supramolecular assemblies, even when they are too large to fully enter the nanopore.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612056PMC
http://dx.doi.org/10.1039/c7sc01940hDOI Listing

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