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Between the lines: a discursive analysis of the non-specific low back pain literature.
Physiother Theory Pract
January 2025
RECOVER Injury Research Centre, The University of Queensland, Surgical Treatment and Rehabilitation Service (STARS), Herston, Australia.
Background: The term nonspecific low back pain (NSLBP) is often ambiguously defined and inconsistently used in scientific literature. Yet, there is limited discussion and reflection on the meaning of the term and how different meanings influence research and clinical practice.
Aim: The aim of this study was to critically analyze the meaning of NSLBP in scientific literature and its consequent influence on research and clinical practice.
Beyond the Illusion of Controlled Environments: How to Embrace Ecological Pertinence in Research?
Eur J Neurosci
January 2025
Department of Biology, Concordia University, Montreal, QC, Canada.
Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to translate into effective human treatments. Originally designed to address the lack of reproducibility in animal studies, the current global gold standard of rigorous standardization has led to increasingly controlled environments.
View Article and Find Full Text PDFInnovative Approaches in Regulatory Affairs: Leveraging Artificial Intelligence and Machine Learning for Efficient Compliance and Decision-Making.
AAPS J
January 2025
Department of Regulatory Affairs, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Artificial Intelligence (AI) and AI-driven technologies are transforming industries across the board, with the pharmaceutical sector emerging as a frontrunner beneficiary. This article explores the growing impact of AI and Machine Learning (ML) within pharmaceutical Regulatory Affairs, particularly in dossier preparation, compilation, documentation, submission, review, and regulatory compliance. By automating time-intensive tasks, these technologies streamline workflows, accelerate result generation, and shorten the product approval timeline.
View Article and Find Full Text PDFWhat constitutes a medical miseducation? Ten mishaps, readily remedied.
Med Teach
January 2025
Peninsula School of Medicine, Faculty of Health, University of Plymouth, Penzance, Cornwall, United Kingdom.
In adopting reductive instrumentalism as a dominant discourse medical education can be seen to have cultivated a values monoculture resistant to innovation. This culture characteristically retreats to the safety of conservatism rather than diversifying and innovating to embrace values beyond the functional - such as the ethical, aesthetic, and political. Here - where teaching displaces facilitation of learning - training is privileged over education, competence over capability, linearity over complexity, and information over knowledge.
View Article and Find Full Text PDFHypertrophic Cardiomyopathy with Special Focus on Mavacamten and Its Future in Cardiology.
Biomedicines
November 2024
Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland.
Hypertrophic cardiomyopathy (HCM) is a heterogeneous group of heart muscle disorders that affects millions, with an incidence from 1 in 500 to 1 in 200. Factors such as genetics, age, gender, comorbidities, and environmental factors may contribute to the course of this disease. Diagnosis of HCM has improved significantly in the past few decades from simple echocardiographic evaluations to a more complex, multimodal approach embracing advanced imaging, genetic, and biomarker studies.
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