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Community Pharmacists' Knowledge Regarding Donepezil Averse Effects and Self-Care Recommendations for Insomnia for Persons with AD. | LitMetric

AI Article Synopsis

  • Alzheimer's disease (AD) affects millions globally, with acetylcholinesterase inhibitors like donepezil and rivastigmine being the main symptomatic treatments without a cure available.
  • A study surveyed 862 community pharmacists in West Virginia, North Dakota/South Dakota, and Southern Oregon/Northern California to evaluate their knowledge of donepezil's adverse effects (AEs) and insomnia management for AD patients.
  • Results showed only 31.4% of pharmacists could name 2 or more donepezil AEs, and only 62.9% provided appropriate insomnia recommendations, indicating significant gaps in their knowledge that must be addressed for better AD care.

Article Abstract

Alzheimer's disease (AD) impacts millions of individuals worldwide. Since no cure is currently available, acetylcholinesterase inhibitors are symptomatic therapy. This study assessed community pharmacists' knowledge regarding donepezil adverse effects (AEs) and self-care recommendations for insomnia management for persons with AD treated with rivastigmine. This is a cross-sectional, standardized telephone survey of community pharmacists ( = 862) in three study areas: West Virginia, North Dakota/South Dakota, and Southern Oregon/Northern California. Pharmacists' degree, sex, and pharmacists' AD-related knowledge were assessed. In-stock availability of donepezil and rivastigmine formulations was assessed. Analyses were performed using Stata 10.1. Only 31.4% pharmacists were able to name ≥2 donepezil AEs. Only four donepezil AEs were named by at least 13% of pharmacists: nausea (36.1%), dizziness (25.1%), diarrhea (15.0%), and vomiting (13.9%). All other AEs were named by fewer than 7% of respondents. Only 62.9% of pharmacists ( = 542) provided appropriate recommendations: melatonin (40.3%), referral to physician (22.0%), or sleep hygiene (0.6%). Over 12% of pharmacists ( = 107) provided inappropriate recommendations (anticholinergic agent or valerian root) and 21.5% of pharmacists were unable to provide any recommendation. We identified significant gaps in community pharmacists' knowledge regarding donepezil AEs and non-prescription insomnia recommendation needing significant improvement to ensure high-quality AD-related care.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622354PMC
http://dx.doi.org/10.3390/pharmacy5030042DOI Listing

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