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The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology. | LitMetric
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The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology.

Richard A Baylis Delphine Gomez Ziad Mallat Gerard Pasterkamp Gary K Owens

Arterioscler Thromb Vasc Biol

From the Robert M. Berne Cardiovascular Research Center (R.A.B., G.K.O.), Department of Biochemistry and Molecular Genetics (R.A.B.), and Department of Molecular Physiology and Biological Physics (G.K.O.), University of Virginia, Charlottesville; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute (D.G.), Division of Cardiology, University of Pittsburgh School of Medicine, PA (D.G.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (Z.M.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (Z.M.); and Laboratory of Clinical Chemistry, University Medical Centre Utrecht, The Netherlands (G.P.).

Published: November 2017

The results of the CANTOS trial provide exciting evidence in support of the inflammatory hypothesis of atherosclerosis in humans, and is the first phase III clinical trial to show clinical benefit of a targeted anti-inflammatory therapy. However, the modest overall clinical benefit and safety concerns with increased susceptibility to fatal infections indicate that we need much more work in this critical area.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685554PMC
http://dx.doi.org/10.1161/ATVBAHA.117.310097DOI Listing

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