Partial neuromuscular block impairs arytenoid abduction during hypercarbic challenge in anesthetized dogs.

Objective: To evaluate the effect of two levels of partial neuromuscular block (NMB) on arytenoid abduction, tidal volume (V) and peak inspiratory flow (PIF) in response to a hypercarbic challenge in anesthetized dogs.

Study Design: Prospective laboratory study.

Animals: Eleven healthy male Beagle dogs aged 3-5 years.

Methods: Dogs were anesthetized with propofol and dexmedetomidine infusions. The rima glottidis was observed via an endoscope placed through a laryngeal mask airway. Atracurium infusion was titrated to obtain two levels of partial NMB. The normalized glottal gap area (NGGA; glottal gap area normalized to height squared of rima glottidis) at peak inspiration during a hypercarbic challenge (10% CO inspired for 1 minute) was measured at baseline, during mild [train-of-four (TOF) ratio 0.4-0.6] and shallow (TOF ratio 0.7-0.9) NMB, and 30 minutes after spontaneous recovery from NMB. The V and PIF were measured at the same time points and compared using anova for repeated measures and Tukey's post hoc tests.

Results: The NGGA and V were significantly lower than baseline during both levels of partial NMB with no difference between mild and shallow NMB (p < 0.05). They returned to baseline values after spontaneous recovery from NMB. PIF was not altered significantly during partial NMB.

Conclusions And Clinical Relevance: The NGGA and V at peak inspiration in response to a hypercarbic challenge were reduced during partial NMB block, with decreased abduction of the arytenoid cartilages. This dysfunction was present even at shallow levels of NMB.