A procedure to detect general association based on concentration of ranks.

Stat (Int Stat Inst)

Bioinformatics Research Center and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695.

Published: February 2017

In modern high-throughput applications, it is important to identify pairwise associations between variables, and desirable to use methods that are powerful and sensitive to a variety of association relationships. We describe RankCover, a new non-parametric association test of association between two variables that measures the concentration of paired ranked points. Here 'concentration' is quantified using a disk-covering statistic similar to those employed in spatial data analysis. Considerations from the theory of Boolean coverage processes provide motivation, as well as an -like quantity to summarize strength of association. Analysis of simulated and real datasets demonstrate that the method is robust and often powerful in comparison to competing general association tests.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616165PMC
http://dx.doi.org/10.1002/sta4.138DOI Listing

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