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| http://dx.doi.org/10.5021/ad.2017.29.5.635 | DOI Listing |
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Transcription Factor Activity Regulating Macrophage Heterogeneity during Skin Wound Healing.
J Immunol
August 2024
Center for Wound Healing and Tissue Regeneration, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL.
Article Synopsis
- Monocytes and macrophages (Mos/Mϕs) are crucial for wound healing, exhibiting a range of functional types, but how this variety is controlled is not well understood.
- * The study used a refined model incorporating single-cell RNA and ATAC sequencing to analyze the activity of transcription factors (TFs) in Mos/Mϕs during skin wound healing, identifying distinct clusters for early and late stages of healing.
- * Key findings include the discovery of specific TF networks influencing the behavior of Mos/Mϕs, with NR4A1 shown to play a significant proinflammatory role, as evidenced by altered healing processes in mice lacking this TF.*
Biopolymeric composite hydrogel loaded with silver NPs and epigallocatechin gallate (EGCG) effectively manages ROS for rapid wound healing in type II diabetic wounds.
Int J Biol Macromol
October 2022
Water Analysis Laboratory, System Toxicology, and Health Risk Assessment Group, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Delayed wound healing in patients having type-II diabetes mellitus (T2DM) often results in a high rate of amputation. We report an innovative Guar Gum-based macroporous hydrogel (HG) infused with an antibacterial agent (Ag NPs), and antioxidant, epigallocatechin gallate (EGCG) to address rapid wound healing and interestingly could inhibit the associated pathophysical bone infection in a high-fat-diet-induced T2DM C57BL/6 mice model. The HG-Ag-EGCG elicits scar-free wound healing in subcutaneous wounds and histopathological evidence confirmed HG-Ag-EGCG hydrogel patch elicits better wound healing through enhanced cell proliferation, mature connecting tissue fiber formation, minimum void spaces formation, and better re-epithelialization when compared with a market available hydrogel patch material (Luofucon®).
View Article and Find Full Text PDFTherapeutic effects of equine amniotic membrane suspension on corneal re-epithelialization and haze in a modified lagomorph ex vivo wound healing model.
Vet Ophthalmol
March 2022
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Objective: To investigate the therapeutic effects of topical equine amniotic membrane (eAM) suspension following corneal wounding in a controlled experimental setting.
Procedures: Equine amniotic membrane was collected, gamma irradiated, homogenized for topical suspension preparation, and cryopreserved. Corneoscleral rims harvested from fresh rabbit globes were wounded via keratectomy and were maintained in an air-liquid interface ex vivo corneal culture model.
The effects of Platelet-rich Plasma on healing of partial thickness burns in a porcine model.
Ann Burns Fire Disasters
December 2018
Department of Emergency Medicine, Stony Brook University, Stony Brook, NY, USA.
Platelet-rich plasma (PRP) derived from autologous peripheral blood is rich in platelets that release growth factors and cytokines. We determined the effects of topically applied autologous PRP in a partial thickness porcine burn model. Partial thickness burns were created on the backs and flanks of six domestic pigs (24 burns each) using an aluminium bar preheated to 80° C for 20 seconds.
View Article and Find Full Text PDFEffectiveness of bitter melon extract in the treatment of ischemic wounds in rats.
Turk J Biol
December 2018
Department of Histology and Embryology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar , Turkey.
Article Synopsis
- The study aimed to evaluate the effectiveness of different wound dressings, specifically bitter melon extract with olive oil, pure olive oil, nitrofurazone, and saline, on ischemic wounds in rats.
- A total of 48 rats were treated, and results showed that the group with bitter melon extract achieved the highest wound healing rate (94.7%), while the nitrofurazone group had the lowest (86.3%).
- It was concluded that bitter melon extract is the most effective dressing for wound healing, outperforming nitrofurazone and saline, while pure olive oil also helps speed up the healing process but less effectively than bitter melon extract.
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