Background: A new method in mandible reconstruction has recently been developed using patient-specific mandible reconstruction plates (PSMP) after preoperative computer planning using CAD/CAM procedures. To transfer the virtual planned position of the PSMP into the intraoperative situs resection margins and plate position is determined by using surgical guides made by CAD/CAM procedures as well (PSMP-method).
Methods: Mandibular reconstruction with the PSMP-method was performed on 18 patients. The study included sole alloplastic reconstruction cases (AP, n = 10) and microvascular osseous reconstruction cases (MV, n = 8). Pre- and postoperative CT-scans were evaluated by measuring distances between corresponding landmarks on the mandibular rami. The difference was used to evaluate reconstruction accuracy.
Results: The median deviation of all distances was 1.13 mm for PSMP-method including all cases. For AP-group, the median deviation was 0,80 mm, for MV-group it was 2,47 mm. There was a high significant difference between both groups (AP and MV). Larger mandibular resections in combination with the need of positioning the surgical guides in the region of the upper condyle seemed to reduce reconstruction-accuracy. This was found more often in MV-group as in the AP-group.
Conclusions: PSMP-method seems to be an effective and satisfying method for accurate mandibular reconstruction. Microvascular reconstruction seems less accurate than sole alloplastic reconstruction. Larger resections of the mandible and technical more challenging approaches up to the mandibular condyle might explain this result.
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http://dx.doi.org/10.1016/j.jcms.2017.08.028 | DOI Listing |
Syst Biol
January 2025
Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.
Obtaining a timescale for bacterial evolution is crucial to understand early life evolution but is difficult owing to the scarcity of bacterial fossils. Here, we introduce multiple new time constraints to calibrate bacterial evolution based on ancient symbiosis. This idea is implemented using a bacterial tree constructed with genes found in the mitochondrial lineages phylogenetically embedded within Proteobacteria.
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December 2025
Department of Joint and Sports Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.
As life expectancy among patients infected with the human immunodeficiency virus (HIV) increases, a growing number of complications have been observed. This population displays an elevated risk of ischemic necrosis of the femoral head in comparison to the general population, which may be attributed to HIV infection, antiretroviral medication use, and hormone application. Patients infected with the human immunodeficiency virus (HIV) who also have necrosis of the femoral head tend to present at an earlier age, with a rapid disease progression and a high incidence of bilateral onset.
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January 2025
Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637.
Many proteins form paralogous multimers-molecular complexes in which evolutionarily related proteins are arranged into specific quaternary structures. Little is known about the mechanisms by which they acquired their stoichiometry (the number of total subunits in the complex) and heterospecificity (the preference of subunits for their paralogs rather than other copies of the same protein). Here, we use ancestral protein reconstruction and biochemical experiments to study historical increases in stoichiometry and specificity during the evolution of vertebrate hemoglobin (Hb), an αβ heterotetramer that evolved from a homodimeric ancestor after a gene duplication.
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Department of Anaesthesia, Main-Kinzig-Kliniken, Herzbachweg 14, 63571, Gelnhausen, Germany.
Background: Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain. Pain control is crucial for rapid mobilisation and reduces side effects as well as the length of hospital stay. In this context, a variety of multimodal pain control regimes show good pain relief, including several nerve blocks, iPACK and local infiltration analgesia (LIA).
View Article and Find Full Text PDFHernia
January 2025
Department of Surgery, Corewell Health East William Beaumont University Hospital, 3601 W 13 Mile Road, Royal Oak, MI, 48073, USA.
Purpose: Traumatic abdominal intercostal/flank hernias present a perplexing challenge for surgeons seeking to repair them. There has been a paucity of studies describing robotic repairs of such hernias. We aim to evaluate the effectiveness of the Robotic-assisted Extended Total Extraperitoneal/Transversus Abdominus Release (rETEP/TAR) method in repairing traumatic abdominal intercostal and flank hernias.
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