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A simple sore can lead to limb amputation; metastatic squamous cell carcinoma of the sole in a 22-year-old man.
Int J Surg Case Rep
November 2024
Department of Nursing, School of Nursing and Midwifery, Shahrekord University of Medical Sciences, 9W46+PXW, Shahrekord, Chaharmahal and Bakhtiari Province, Iran. Electronic address:
Article Synopsis
- - Squamous cell carcinoma (SCC) is a type of skin cancer that can arise from genetic mutations in normal skin cells and is usually found in sun-exposed areas, though it can appear in unexpected locations, such as the soles of the feet.
- - A 22-year-old man presented with a non-healing sore on his foot, which worsened over time and was ultimately diagnosed as metastatic SCC that spread to his lungs and lymph nodes.
- - This case emphasizes the importance of considering cancer in persistent wounds, particularly in young patients, and highlights the need for early detection and comprehensive treatment strategies.
Diagnostic challenges in cutaneous leishmaniasis due to atypical : pathologists' insights from re-emergence zones.
Front Med (Lausanne)
September 2024
Division of Malaria Immunology, Department of Microbiology and Immunology, Institute of Medical Science (IMSUT), The University of Tokyo, Tokyo, Japan.
Article Synopsis
- - The study focuses on the rising incidence of cutaneous leishmaniasis (CL) in Türkiye due to migration and environmental changes, noting that it’s appearing in places where it was previously unknown, leading to misdiagnosis by physicians unfamiliar with the disease.
- - Researchers performed a retrospective analysis of 12 CL cases diagnosed from 2013 to 2022, looking at clinical presentation, pre-diagnosis, histopathological findings, and DNA analysis to confirm species involved.
- - Findings show that only 58.3% of cases considered CL in their pre-diagnosis; others were misdiagnosed, often as skin tumors, with patients presenting non-healing skin lesions that required further evaluation.
Many faces of cutaneous leishmaniasis.
Postgrad Med J
September 2024
Department of Medical Microbiology, Harran University Medical Faculty, Şanlıurfa 63000, Turkey.
Article Synopsis
- This study aimed to identify atypical clinical presentations of cutaneous leishmaniasis (CL) in Şanlıurfa province, encompassing a retrospective analysis of 213 patients with non-standard symptoms out of 1,751 diagnosed cases between 2019 and 2022.
- The prevalence of atypical CL was found to be 12.1%, with common atypical lesions including lupoid, erysipeloid, and impetiginous types, along with many others resembling various skin conditions and diseases.
- The research highlights that CL can mimic a wide range of infectious, inflammatory, and neoplastic disorders, stressing the importance of thorough differential diagnosis for persistent non-healing skin lesions, especially in areas where CL is
Malignant wound aetiology, diagnosis and management: a case series and literature review.
J Wound Care
February 2024
University of Toledo, College of Medicine and Life Science, Toledo, Ohio, US.
Objective: Malignant wounds develop when neoplastic cells invade the skin either locally or by lymphatic and haematogenous spread. They can present as hard-to-heal wounds and underlying causes include: primary skin cancer; metastasis of extracutaneous primary malignancy; malignant transformation of a hard-to-heal wound; iatrogenic injury; and cutaneous forms of cancers of non-skin origin. High clinical suspicion for a malignant wound should be confirmed with skin biopsy.
View Article and Find Full Text PDFBurkholderia-associated polymyositis.
BMJ Case Rep
January 2024
Pathology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India.
A diagnosis of polymyositis can readily be made when there is a typical history of proximal muscle weakness together with clinical findings, and there is corroboratory evidence in the form of elevated creatine kinase lactate dehydrogenase, aldolase, and serum glutamic-oxaloacetic transaminase (aspartate aminotransferase). A muscle biopsy usually helps in making the confirmatory diagnosis. A female in her 50s presented with non-healing multiple deep necrotic ulcers with muscle weakness.
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