Citrinal B, a tricyclic compound from endophytic fungus Colletotrichum capsici in our previous studies, exhibited significant inhibitory activity against 11β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1) in vitro and showed strong binding affinity to 11β-HSD1. Moreover, citrinal B treatments decreased the lipid droplet accumulation associate with the inhibition of 11β-HSD1 expression in differentiate induced 3T3-L1 preadipocytes. Furthermore, the molecular docking demonstrated that citrinal B coordinated in the active site of 11β-HSD1 is essential for the ability of diminishing the enzyme activity.
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| http://dx.doi.org/10.1016/j.fitote.2017.09.018 | DOI Listing |
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Citrinal B, natural 11 beta-hydroxysteroid dehydrogennase type 1 inhibitor identified from structure-based virtual screening.
Fitoterapia
November 2017
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Citrinal B, a tricyclic compound from endophytic fungus Colletotrichum capsici in our previous studies, exhibited significant inhibitory activity against 11β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1) in vitro and showed strong binding affinity to 11β-HSD1. Moreover, citrinal B treatments decreased the lipid droplet accumulation associate with the inhibition of 11β-HSD1 expression in differentiate induced 3T3-L1 preadipocytes. Furthermore, the molecular docking demonstrated that citrinal B coordinated in the active site of 11β-HSD1 is essential for the ability of diminishing the enzyme activity.
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