AI Article Synopsis
- Spreading depolarization in the cerebral cortex involves neuron swelling, dendritic spine distortion, and significant changes in electrical activity.
- It leads to a phenomenon called spreading depression, which is a wave of reduced electrical activity that spreads across the brain's gray matter.
- While they're related, spreading depolarization and spreading depression are distinct processes; one does not always result in the other.
Article Abstract
Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates through contiguous cerebral gray matter at a characteristic velocity. Spreading depression is a consequence of cortical spreading depolarization. Therefore, spreading depolarization is not always accompanied by spreading depression and the terms are not synonymous.
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| http://dx.doi.org/10.1016/j.ncl.2017.06.004 | DOI Listing |
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