Unlabelled: Cancer has genetic and environmental causes, one of which is the ingestion of heavy metals such as cadmium.
Objective: To evaluate the lesions caused by cadmium poisoning in the digestive tract and the possible effect of the drinking water pH in the initiation of these lesions.
Methods: 90 male Wistar rats were used, divided into six groups (= 15): A - received 400 mg/l cadmium chloride (CdCl2) in drinking water at a neutral pH of 7.0; B - received CdCl2 (400 mg/l) in drinking water at an acidic pH of 5.0; C - received CdCl2 (400 mg/l) in drinking water at a basic pH of 8.0; D - received water at an acidic pH of 5.0; E - received water at a basic pH of 8.0; and F - received water at a neutral pH of 7.0. Animals were euthanized after 6 months. Samples of the esophagus, stomach, small intestine and large intestine of each rat were removed for microscopic analysis.
Results: There were no microscopic changes in either the esophagus or small and large intestines. Only cadmium-exposed animals showed mild dysplasia of the gastric mucosa (= 0.012), regardless of the pH (> 0.05).
Conclusion: Cadmium exposure led to the formation of dysplastic lesions in the gastric glandular epithelium, regardless of the water pH.
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| http://dx.doi.org/10.1016/j.toxrep.2015.07.012 | DOI Listing |
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