Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for studies was characterized and monitored by H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598257 | PMC |
| http://dx.doi.org/10.1016/j.toxrep.2015.01.009 | DOI Listing |
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