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Self-Assembly of Novel Thiophene-Based BODIPY Ru Rectangles: Potential Antiproliferative Agents Selective Against Cancer Cells. | LitMetric
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Self-Assembly of Novel Thiophene-Based BODIPY Ru Rectangles: Potential Antiproliferative Agents Selective Against Cancer Cells.

Gajendra Gupta Abhishek Das Sourav Panja Ji Yeon Ryu Junseong Lee Nripendranath Mandal Chang Yeon Lee

Chemistry

Department of Energy and Chemical Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, 22012, Republic of Korea.

Published: December 2017

Novel Ru (2+2) rectangles were designed and synthesized by self-assembly of a new thiophene-functionalized dipyridyl BODIPY ligand, BDPS, and ruthenium(II) precursors. The complexes exhibited dose-dependent antiproliferative activities against cancer cells, in which some compounds selectively kill cancer cells. The net fluorescence due to BODIPY allowed us to visualize their location inside cancer cells. Moreover, the metalla-rectangles displayed substantial propensity to bind with biomolecules.

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 Source
http://dx.doi.org/10.1002/chem.201704368DOI Listing

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