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A 3-MicroRNA Signature Identified From Serum Predicts Clinical Outcome of the Locally Advanced Gastric Cancer.
Front Oncol
June 2020
Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Current staging systems are inadequate for evaluating the prognosis of patients with locally advanced gastric cancer (LAGC, stages II-III). Therefore, we developed a serum microRNA (miRNA) signature to facilitate individualized management of these patients. Using microarray analysis, we analyzed 12 serum specimens based on different prognoses (good survival group, = 7; poor survival group, = 5).
View Article and Find Full Text PDFIn silico analysis identified miRNA‑based therapeutic agents against glioblastoma multiforme.
Oncol Rep
April 2019
Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
MicroRNAs (miRNAs or miRs) contribute to the development of various malignant neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore the pathogenesis of GBM and to identify latent therapeutic agents for patients with GBM, based on an in silico analysis. Gene chips that provide miRNA expression profiling in GBM were obtained from the Gene Expression Omnibus (GEO) database.
View Article and Find Full Text PDFIdentification of Serum MicroRNAs as Novel Biomarkers in Esophageal Squamous Cell Carcinoma Using Feature Selection Algorithms.
Front Oncol
January 2019
Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.
Circulating microRNAs (miRNAs) are promising molecular biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC). We investigated the serum miRNA expression profiles from microarray-based technologies and evaluated the diagnostic value of serum miRNAs as potential biomarkers for ESCC by using feature selection algorithms. Serum miRNA expression profiles were obtained from 52 ESCC patients and 52 age- and sex-matched controls via performing a high-throughput microarray assay.
View Article and Find Full Text PDFA three-miRNA-based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) RUNX1-RUNX1T1 acute myeloid leukaemia.
Br J Haematol
October 2018
Women and Child Health Department, Haematology-Oncology Clinic and Laboratory, University of Padova, Padova, Italy.
Evidence for the relationship between the regulatory effects of microRNAs and attack robustness of biological networks.
Comput Biol Med
August 2015
School of Biology, College of Science, University of Tehran, Tehran, Iran. Electronic address:
It has been previously suggested that microRNAs (miRNAs) have a tendency to regulate the important components of biological networks. The goal of the present study was to systematically test if one can establish a relationship between miRNA targets and the important components of biological networks (including human protein-protein interaction network, signaling network and metabolic network). For this analysis, we have studied the attack robustness of these networks.
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