Population-genetic investigation was carried out in the regions endemic for Viljuisk encephalomyelitis (VE). The following indices were estimated: the relationship coefficient, the inbreeding coefficient, the intensity of migration, genetic structure of the population. The aim of the investigation was to explain causes of intrapopulational and, in some cases, of intragenus accumulation of the VE patients. No evidence of isolation or increased inbreeding were found in highly affected populations. The genetic structure of a group of VE patients tested for 9 polymorphic systems did not reveal any deviation from the control group. Several VE cases in healthy populations occured in some years after the immigration of a VE patient. These data confirm the hypothesis that VE is transmitted from a VE patient to healthy persons. Among these persons fall ill those who have a hereditary determined increased sensitivity to VE which results in intrapopulation and intragenus accumulation of VE cases.
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Human Vilyuisk encephalitis.
Rev Med Virol
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Department of Neurology, University of Illinois at Chicago School of Medicine, Chicago, IL 60612-7344, USA.
For more than a century, a type of human encephalomyelitis has been known to affect indigenous people in the Sakha Republic in the Vilyui River Valley in Russia. The clinical features, laboratory findings, neuropathology, epidemiology and search for a causative pathogen are reviewed. One of the agents (Vilyuisk human encephalitis virus; VHEV) implicated in Vilyuisk encephalitis, belongs to a separate clade of Theiler's murine encephalomyelitis virus (TMEV).
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Vestn Ross Akad Med Nauk
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