We examined whether AN69ST (acrylonitrile and methallyl sulfonate copolymer) membranes adsorb nafamostat mesilate. This study retrospectively analyzed 87 continuous hemodiafiltration sessions in vivo. We divided the continuous hemodiafiltration sessions into AN69ST and non-AN69ST groups using the nafamostat mesilate dose and activated clotting time as indicators of nafamostat mesilate adsorption onto the membrane. Furthermore, we studied the in vitro adsorption of nafamostat mesilate from nafamostat mesilate solutions onto four different hemodialysis membranes. This in vivo study shows that nafamostat mesilate doses were significantly higher, but activated clotting times were shorter (P < 0.001) in the AN69ST group than in the non-AN69ST group. These results suggest that AN69ST adsorbs nafamostat mesilate. Further, the in vitro experiments show that nafamostat mesilate adsorbs AN69ST on membranes significantly more than the other membranes tested. These in vitro and clinical findings provide evidence that AN69ST may adsorb nafamostat mesilate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1744-9987.12587 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Anticoagulation effects of nafamostat mesylate in sustained low-efficiency dialysis and its relevant factors].
Zhonghua Yi Xue Za Zhi
January 2025
Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Medical Center of Kidney, Shanghai200032, China.
To investigate anticoagulation effects of nafamostat mesylate(NM) in sustained low-efficiency dialysis (SLED) and its relevant factors. Critically ill patients with kidney disease who were admitted to Zhongshan Hospital Affiliated to Fudan University and underwent SLED treatment from May to August 2024 were retrospectively included. Baseline clinical data were collected, and the activated partial thromboplastin time (APTT) and activated clotting time (ACT) were measured at the arterial end, before the filter, and at the venous end two hours post-NM anticoagulation treatment.
View Article and Find Full Text PDFThe identification of insect specific iAANAT inhibitors.
Arch Biochem Biophys
December 2024
Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA. Electronic address:
An important aspect of food security is the development of innovative insecticides, particularly ones that specifically target insect pests and exhibit minimal toxicity to mammals. The insect arylalkylamine N-acyltransferases (iAANATs) could serve as targets for novel insecticides that satisfy these criteria. There exists a wealth of structural and biochemical information for the iAANATs and iAANAT knockdown experiments show that these enzymes are critical to insect health.
View Article and Find Full Text PDFBroad-Spectrum Detoxification of Snake Venoms With Supramolecular Materials Integrated via Molecular Recognition and Coassembly.
Adv Healthc Mater
December 2024
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.
Article Synopsis
- Snakebite is a serious medical issue in tropical and subtropical areas, requiring specific antivenoms to combat various snake venoms, which is both clinically and financially challenging.!* -
- A new broad-spectrum antidote was developed using a combination of coassembled compounds to neutralize four toxic snake venom types, improving the effectiveness of treatment.!* -
- The antidote demonstrated successful toxin neutralization in trials, enhancing survival rates of mice exposed to poisonous snake venom, highlighting the potential for broader applications in snakebite treatment.!*
New strategy of early surgery for infective endocarditis complicated by intracranial hemorrhage.
Surg Today
November 2024
Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 2-5-7, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Purpose: Early surgery for infective endocarditis with intracranial hemorrhage can cause severe bleeding, which is correlated with an increased mortality. In 2005, we started using nafamostat mesilate and low-dose heparin as anticoagulants during cardiopulmonary bypass for early surgery. The outcomes of this strategy have been reviewed.
View Article and Find Full Text PDFThe respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids.
J Virol
November 2024
Department of Microbiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Unlabelled: A critical aspect of the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the protease-mediated activation of the viral spike (S) protein. The type II transmembrane serine protease TMPRSS2 is crucial for SARS-CoV-2 infection in lung epithelial Calu-3 cells and murine airways. However, the importance of TMPRSS2 needs to be re-examined because the ability to utilize TMPRSS2 is significantly reduced in the Omicron variants that spread globally.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!