Indoline based donor-acceptor system (InBT) exhibits a colour transition from pink to orange to yellow in chloroform facilitated by the photo-oxidation of the N,N-dimethyl indoline of InBT and neutralized by chloride counter ions upon light irradiation at short and long range excitation wavelengths of 320 and 500 nm, which leads to spherical aggregates when subjected to methanol vapour diffusion (MVD).
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http://dx.doi.org/10.1039/c7cp04988a | DOI Listing |
Alzheimers Dement
December 2024
The University of Sydney, Sydney, NSW, Australia.
Background: SMOC1 has recently emerged as one of the most significant and consistent new biomarkers of early Alzheimer's disease (AD). SMOC1 is one of the earliest changing proteins in AD, with SMOC1 cerebrospinal fluid levels increasing 29 years before symptom onset in autosomal dominant AD. Despite this clear association with disease, very little is known about the role of SMOC1 in AD or its function in the brain.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, Shosha, Himeji, Hyogo 671-2201, Japan.
To prepare amphiphilic diblock copolymers (MP), a controlled radical polymerization approach was employed, incorporating hydrophilic poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) with hydrophobic poly(3-methoxypropyl acrylate) (PMPA). The synthesized diblock copolymers feature a PMPC block with a degree of polymerization (DP) of 100 and a PMPA block with DP (=) values of 171 and 552. The hydrophilic PMPC block exhibits biocompatibility, such as inhibition of platelet and protein adsorption, because of its hydrophilic pendant zwitterionic phosphorylcholine groups that have the same chemical structure as cell membrane surfaces.
View Article and Find Full Text PDFInt J Pharm
December 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China; Faculty of Health Sciences, University of Macau, Macau 999078, China. Electronic address:
Messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) represents a cutting-edge delivery technology that played a pivotal role during the COVID-19 pandemic and in advancing vaccine development. However, molecular structure of mRNA-LNPs at real size remains poorly understood, with conflicting results from various experimental studies. In this study, we aim to explore the assembly process and structural characteristics of mRNA-LNPs at realistic sizes using coarse-grained molecular dynamic simulations.
View Article and Find Full Text PDFMacromolecules
December 2024
Dainton Building, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, South Yorkshire S3 7HF, U.K.
We report the reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in -dodecane using a poly(lauryl methacrylate) (PLMA) precursor at 90 °C. This formulation is an example of polymerization-induced self-assembly (PISA), which leads to the formation of a colloidal dispersion of spherical PLMA-PHEMA nanoparticles at 10-20% w/w solids. PISA syntheses involving polar monomers in non-polar media have been previously reported but this particular system offers some unexpected and interesting challenges in terms of both synthesis and characterization.
View Article and Find Full Text PDFChem Asian J
December 2024
Department of chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, West Bengal, India.
Metal-organic gels (MOGs) are a type of supramolecular complex that have become highly intriguing due to their synergistic combination of inorganic and organic elements. We report the synthesis and characterization of a Ni-directed supramolecular gel using chiral amino acid L-DOPA (3,4-dihydroxy phenylalanine) containing ligand, which coordinates with Ni(II) to form metal-organic gels with exceptional properties. The functional Ni(II)-gel was synthesized by heating nickel(II) acetate hexahydrate and the L-DOPA containing ligand in DMSO at 70 °C.
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