The [VO{(OCH)CCHOCHC[triple bond, length as m-dash]CH}] with two terminal alkyne functionalities exhibits excellent reactivity towards (bio-)organic azides. The designed synthetic protocol for the generation of triazol-modified Lindqvist hexavanadates grants access to bio-"clicked" polyoxometalates with spectroscopically detectable V nuclei.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c7dt03376a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives.
PLoS One
August 2017
Department of Organic Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic.
In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodium azides produced 30-azidoderivatives and these azides were subjected to CuI catalysed Huisgen 1,3-cycloaddition to give the final conjugates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!