Modelling the dynamics of toxicity associated with aflatoxins in foods and feeds.

Toxicol Rep

Near East University, Faculty of Arts and Sciences, Department of Mathematics, Nicosia, Cyprus.

Published: June 2017

In this paper, we developed a mathematical model to describethe dynamics of Aflatoxins in plants, animals, and humans. Fourequilibrium points were found, and their stability analyses wereconducted using threshold quantities. If both are less than one, thestandardized toxic limit is not exceeded, while if both are greater thanone it is exceeded in both animals and humans. Standardized toxic limitis exceeded in a relevant host (animals or humans) when their respectivethreshold quantity is greater than one. Numerical simulations werecarried out to support the analytic results. The need to use experimentaldata in the model is also shown. This could ease satisfactoryharmonization of acceptable standards and facilitate international tradeof food and feeds.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615152PMC
http://dx.doi.org/10.1016/j.toxrep.2017.05.009DOI Listing

Publication Analysis

Top Keywords

animals humans
12
modelling dynamics
4
dynamics toxicity
4
toxicity associated
4
associated aflatoxins
4
aflatoxins foods
4
foods feeds
4
feeds paper
4
paper developed
4
developed mathematical
4

Similar Publications

Evaluation of Enrichment Approaches for the Study of the Viromes in Mollusk Species.

Food Environ Virol

January 2025

Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.

Invasive alien species such as freshwater snails have significantly affected the food, environment, and the health of humans and animals, which have unfortunately received insufficient attention. To facilitate the study of viromes in snail species, we compared the enrichment effect of cesium chloride (CsCl) and sucrose density gradient ultracentrifugations in the recovery of diverse viruses in Pomacea canaliculata and Achatina fulica. First, we showed that CsCl-based ultracentrifugation enriched more virus contigs and reduced the nucleic acid background of the Pomacea canaliculata and was thus beneficial for virus recovery.

View Article and Find Full Text PDF

In-stent restenosis (ISR) following interventional therapy is a fatal clinical complication. Current evidence indicates that neointimal hyperplasia driven by uncontrolled proliferation of vascular smooth muscle cells (VSMC) is a major cause of restenosis. This implies that inhibiting VSMC proliferation may be an attractive approach for preventing in-stent restenosis.

View Article and Find Full Text PDF

The anatomical, histological, and histochemical characteristics of the foregut (FG), midgut (MG), and hindgut (HG), as well as their alterations during the ovarian cycle in female prawns, Macrobrachium rosenbergii, were investigated. The esophagus (ESO), cardia (CD), and pylorus (PY) are the main components of the FG. An epithelium (Ep) with thick cuticle (Cu) layers lining the ESO, and the ESO is encircled by the ESO glands.

View Article and Find Full Text PDF

As several decades of research have shown the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitors alone or in combination with diuretics, we were interested in investigating the effects of subchronic therapy of these drugs on ischemia-reperfusion (I/R) damage to the heart, as well as their influence on oxidative status. The research was conducted on 40 spontaneously hypertensive male Wistar Kyoto rats, divided into 4 groups. Animals were treated for four weeks with 10 mg/kg/day zofenopril alone or in combination with hydrochlorothiazide, indapamide and spironolactone per os.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!